主任医师，教授，博士生导师。现任西安交通大学第一附属医院副院长。入选首批教育部 “新世纪人才”，西安交通大学“腾飞人才”特聘教授，获日本医学会“海外青年科学家奖”荣誉称号，国家杰出青年科学基金获得者。主要从事动脉粥样硬化的炎症免疫学发病机制研究。研究成果以第一或通讯作者在Nature Medicine 、J Am Coll Cardiol 、Cardiovascular Research 、ATVB 等国际高水平核心期刊（SCI 收录）发表，主编、参编专著和教材共8部，担任9种国际核心刊物审稿人。先后主持和指导完成国家“973”项目、教育部“985”建设工程项目、国家科技攻关项目1项、国家自然科学基金面上项目5项，并获国际交流基金1项，国际合作研究基金2项。现为国际心脏研究会（IHRS ）会员、美国心脏协会（AHA ）会员、欧洲心脏病学会（ESC ）会员、日本循环学会（JCA ）会员、国际动脉粥样硬化协会（IAS ）中国分会副主席、中华医学会心血管病分会常委。2015年9月当选美国心脏病学院（FACC ）Fellow 。
1. Wu Y, Song P, Zhang W, Liu J, Dai X, Liu Z, Lu Q, Ouyang C, Xie Z, Zhao Z, Zhuo X, Viollet B, Foretz M, Wu J, Yuan Z*., Zou MH. Activation of AMPKα2 in adipocytes is essential for nicotine-induced insulin resistance in vivo. Nat Med. 2015; 21(4):373-82. (Correspondence author)
2. Zhang J, Dong J, Martin M, He M, Gongol B, Marin TL, Chen L, Shi X, Yin Y, Shang F, Wu Y, Huang HY, Zhang J, Zhang Y, Kang J, Moya EA, Huang HD, Powell FL, Chen Z, Thistlethwaite PA, Yuan ZY*, Shyy JY. AMPK Phosphorylation of ACE2 in Endothelium Mitigates Pulmonary Hypertension. Am J Respir Crit Care Med. 2018 33(3):550-8.(Correspondence author)
3. Gao S, Liu W, Zhuo X, Wang L, Wang G, Sun T, Zhao Z, Liu J, Tian Y, Zhou J, Yuan Z*, Wu Y. The activation of mTOR is required for monocyte pro-inflammatory response in patients with coronary artery disease. Clin Sci (Lond). 2015 ;128(8):517-26. (Correspondence author)
4. Liu F, Lian Q, Ren J, Ren K, Wang Y, Wang D, Chu C, Wang L, Guo T, Liu E, Mu J, Yuan Z. Lack of family-based association between common variations in WNK1 and blood pressure level. Med Sci Monit. 2014; 20:1958-62
5. Gao S, Wang L, Liu W, Wu Y, Yuan Z*. The synergistic effect of homocysteine and lipopolysaccharide on the differentiation and conversion of raw264.7 macrophages. J Inflamm (Lond). 2014; 11:13. (Correspondence author)
6. Liu J, Zhuo XZ, Liu W, Wan Z, Wang X, Zhang W, Gao S, Yuan Z*, Wu Y. Drug-eluting stent, but not bare metal stent, accentuates the systematic inflammatory response in patients. Cardiology. 2014; 128(3):259-65. (Correspondence author)
7. Zhang Z, Wei S, Gui H, Yuan Z*, Li S. The contribution of genetic diversity to subdivide populations living in the silk road of China. PLoS One. 2014; 9(5):e97344. (Correspondence author)
8. Liu F, Ren J, Wang Y, Yuan Z, Mu J. Severe right axis deviation during acute myocardial infarction. Int J Cardiol. 2014; 174(2):e57-8.
9. Chen F, Guo N, Cao G, Zhou J, Yuan Z*. Molecular analysis of curcumin-induced polarization of murine RAW264.7 macrophages. J Cardiovasc Pharmacol. 2014; 63(6):544-52. (Correspondence author)
10. Feng X, Yuan Y, Wang C, Feng J, Yuan Z, Zhang X, Sui W, Hu P, Zheng P, Ye J. Autophagy involved in lipopolysaccharide-induced foam cell formation is mediated by adipose differentiation-related protein. Lipids Health Dis. 2014; 13:10.
11. Wang H, Liu Y, Zhu L, Wang W, Wan Z, Chen F, Wu Y, Zhou J, Yuan Z*. 17β-estradiol promotes cholesterol efflux from vascular smooth muscle cells through a liver X receptor α-dependent pathway. Int J Mol Med. 2014; 33(3):550-8 (Correspondence author)
12. Wan Z, Liu X, Wang X, Liu F, Liu W, Wu Y, Pei L, Yuan Z*. Small Artery Elasticity Predicts Future Cardiovascular Events in Chinese Patients With Angiographic Coronary Artery Disease. Angiology. 2014; 65(4):298-302. [Epub ahead of print] (Correspondence author)
13. Zhuo XZ, Wu Y, Ni YJ, Liu JH, Gong M, Wang XH, Wei F, Wang TZ, Yuan Z, Ma AQ, Song P. Isoproterenol instigates cardiomyocyte apoptosis and heart failure via AMPK inactivation-mediated endoplasmic reticulum stress. Apoptosis. 2013; 18(7):800-10.
14. He M, Liang X, He L, Wen W, Zhao S, Wen L, Liu Y, Shyy JY, Yuan Z*. Endothelial Dysfunction in Rheumatoid Arthritis: The Role of Monocyte Chemotactic Protein-1-Induced Protein. Arterioscler Thromb Vasc Biol. 2013; 33(6):1384-91. (Correspondence author)
15. Wang L, Gao S, Xu W, Zhao S, Zhou J, Wang N, Yuan ZY*. Allergic asthma accelerates atherosclerosis by modulating the balance of effector and regulatory T cells in apolipoprotein E deficient mice. J Mol Cell Cardiol. 2014; 72:20-7. (Correspondence author)
16. Wang XH , Liu WM, Wu Y, Liu XJ, Liang X, Wan ZF, Wang NP, Yuan ZY*. C-reactive protein reduces protein S-nitrosylation in endothelial Cells. Mol Cell Biochem 2013; 375:131–138. (Correspondence author)
17. X Liang, M He, T. Chen, Y Wu, Y Tian, Y Zhao, Y Shen, Y Liu, Z Yuan*. 17β-Estradiol Suppresses the Macrophage Foam Cell Formation Associated with SOCS3. Horm Metab Res. 2013; 45:423-429. (Correspondence author)
18. Liang X, He M, Chen T, Liu Y, Tian YL, Wu YL, Zhao Y, Shen Y, Yuan ZY*. Multiple roles of SOCS proteins: Differential expression of SOCS1 and SOCS3 in atherosclerosis. Int J Mol Med. 2013 May;31(5):1066-74. (Correspondence author)
19. Zhang WP, Bai XJ, Zheng XP, Xie XL, Yuan ZY*. Icariin Attenuates the Enhanced Prothrombotic State in Atherosclerotic Rabbits Independently of Its Lipid-Lowering Effects. Planta Med 2013; 79: 1–6. (Correspondence author)
20. Wan Z, Liu X, Wang X, Liu F, Liu W, Wu Y, Pei L, Yuan Z*. Small Artery Elasticity Predicts Future Cardiovascular Events in Chinese Patients With Angiographic Coronary Artery Disease. Angiology. 2013 Feb 20. [Epub ahead of print] (Correspondence author)
21. Zhuo XZ, Wu Y, Ni YJ, Liu JH, Gong M, Wang XH, Wei F, Wang TZ, Yuan Z. Isoproterenol instigates cardiomyocyte apoptosis and heart failure via AMPK inactivation-mediated endoplasmic reticulum stress. Apoptosis. 2013 Apr 26. [Epub ahead of print]
22. Cao Y, Mu JJ, Fang Y, Yuan ZY, Liu FQ. Impact of High Salt Independent of Blood Pressure on PRMT/ADMA/DDAH Pathway in the Aorta of Dahl Salt-Sensitive Rats. Int J Mol Sci. 2013 Apr 12;14(4):8062-72.
23. Xu B, Yang Y, Yuan Z, Du Z, Wong SC, Généreux P, Lu S; RESOLUTE China RCT Investigators.Zotarolimus-Eluting and Paclitaxel-Eluting Stents in an All-Comer Population in China: RESOLUTE China Randomized Controlled Trial. JACC Cardiovasc Interv. 2013 Mar 15. doi:pii: S1936-8798(13)00456-1. 10.1016/j.jcin.2013.03.001. [Epub ahead of print]
24. Chen SL, Xu B, Han YL, Sheiban I, Zhang JJ, Ye F, Kwan TW, Paiboon C, Zhou YJ, Lv SZ, Dangas GD, Xu YW, Wen SY, Hong L, Zhang RY, Wang HC, Jiang TM, Wang Y, Chen F, Yuan ZY, Li WM, Leon MB. Comparison of Double Kissing Crush Versus Culotte Stenting for Unprotected Distal Left Main Bifurcation Lesions: Results From a Multicenter, Randomized, Prospective DKCRUSH-III Study. J Am Coll Cardiol. 2013;61(14):1482-8.
25. Chen T, Ding G, Yuan Z*. Insulin ameliorates miR1induced injury in H9c2 cells under oxidative stress via Akt activation. Mol Cell Biochem. 2012;369(1-2):167-74. (Correspondence author)
26. Wang X, Liu X, Kishimoto C, Yuan Z*.The role of Fcγ receptors in atherosclerosis. Exp Biol Med. 2012 ; 237(6):609-16. (Correspondence author)
27. Chen T, Jin X, Yuan Z*. Cardioprotection from oxidative stress in the newborn heart by activation of PPARγ is mediated by catalase. Free Radic Biol Med. 2012 ;53(2):208-15. (Correspondence author)
28. Zhang Y, Hu G, Yuan Z, Chen L.Glycosylated hemoglobin in relationship to cardiovascular outcomes and death in patients with type 2 diabetes: a systematic review and meta-analysis. PLoS One. 2012;7(8):e42551.
29. Liu F, Zheng S, Mu J, Chu C, Wang L, Wang Y, Xiao H, Wang D, Cao Y, Ren K, Liu E, Yuan Z Common variation in with no-lysine kinase 1 (WNK1) and blood pressure responses to dietary sodium or potassium interventions- family-based association study. Circ J. 2012;77(1):169-74.
30. Liu F, Mu J, Yuan Z, Wu G, Liu E, Zheng S, Lian Q, Ren K, Xu H. High salt intake fails to enhance plasma adiponectin in normotensive salt-sensitive subjects. Nutrition. 2012; 28(4): 422-5.
31. Liu F, Mu J, Yuan Z, Zhang M, Zheng S, Lian Q, Liu E, Xu H, Ren K, Huang Q. Potassium supplement ameliorates salt-induced haemostatic abnormalities in normotensive subjects. Acta Cardiol. 2011 Oct;66(5):635-9.
32. Liu F, Mu J, Yuan Z, Lian Q, Zheng S, Wu G, Liu E. Involvement of the lymphatic system in salt-sensitive hypertension in humans. Med Sci Monit. 2011 Oct; 17(10): CR542-6.
33. Zhu JR, Sun NL, Yuan Z, et al. Efficacy and safety of aliskiren, a direct renin inhibitor, compared with ramipril in Asian patients with mild to moderate hypertension. Hypertens Res. 2012 Jan ;35(1):28-33.
34. Wu Y, Zhang W, Liu W, Zhuo X, Zhao Z, Yuan Z*. The double-faced metabolic and inflammatory effects of standard drug therapy in patients after percutaneous treatment with drug-eluting stent. Atherosclerosis. 2011 Mar; 215(1):170-5.
35. Shen Y, Yuan Z*. Antiatherogenic effect of pioglitazone on uremic apolipoprotein E knockout mice by modulation of the balance of regulatory and effector T cells. Atherosclerosis. 2011 Oct; 218(2):330-8. (Correspondence author)
36. Zhao Z, Wu Y, Cheng M, Ji Y, Yang X, Liu P, Jia S, Yuan Z*. Activation of Th17/Th1 and Th1, but not Th17, is associated with the acute cardiac event in patients with acute coronary syndrome. Atherosclerosis. 2011 Aug;217(2):518-24. (Correspondence author)
37. Yan GX, Yuan Z*. Inhibition of triggered activities in pulmonary veins do statins have a direct and clinically relevant antiarrhythmic effect? J Am Coll Cardiol. 2011 Feb 22; 57(8):994-5. (Correspondence author)
38. Jia S, Lian J, Guo D, Xue X, Patel C, Yang L, Yuan Z, Ma A, Yan GX. Modulation of the late sodium current by ATX-II and ranolazine affects the reverse use-dependence and proarrhythmic liability of IKr blockade. Br J Pharmacol. 2011 Sep; 164(2):308-16.
39. Zhao Y, Liu Y, Zhang W, Xue J, Wu YZ, Xu W, Liang X, Chen T, Kishimoto C, Yuan Z*. WIN55212-2 ameliorates atherosclerosis associated with suppression of pro-inflammatory responses in ApoE-knockout mice. Eur J Pharmacol. 2010 Dec 15; 649(1-3):285-92. (Correspondence author)
40. Zhao Q, Sun C, Xu X, Zhou J, Wu Y, Tian Y, Yuan Z, Liu Z. CD34+ cell mobilization and upregulation of myocardial cytokines in a rabbit model of myocardial ischemia. Int J Cardiol 2011; 152(1):18-23.
41. Shen Y, Yuan ZY*, Aiping Yin, et al. Antiatherogenic effect of pioglitazone on uremic apolipoprotein E knockout mice by modulation of the balance of regulatory and effector T cells. Atherosclerosis 2011,218(2):330–338. (Correspondence author)
42. Liu FQ, Mu JJ, Yuan ZY, Wu GJ, Liu EQ, Zheng SH, Lian QF , Ren KY, Xu HX. High Salt Intake Fail to Enhance Plasma Adiponectin in Normotensive Salt -Sensitive Subjects[J]. Nutrition.2012,28:422-425.
43. Zhu YM, Yuan ZY, Wu H, Zhou DD, Jing GX. Midazolam in rabbits terminates dysrhythmias caused by intracerebroventricular ropivacaine. J Zhejiang Univ Sci B. 2011 Aug;12(8):668-76.
44. Tian YL, Yuan ZY*, Liu Y, Liu WM. Pioglitazone modulates the balance of effector and regulatory T cells in apolipoprotein E deficient mice. Nutr Metab Cardiovasc Dis. 2011 Jan;21(1):25-32. [ Scientific Impact Factor = 3.567 ] (Correspondence author)
45. Xue JH, Yuan ZY*, Liu Y, et al. High glucose impairs the balance between CD36 and ABCG1 in vascular smooth muscle cell, promoting the intracellular lipid accumulation. Cardiovasc Res 2010 Apr 1;86(1):141-50. [ Scientific Impact Factor = 6.127 ] (Correspondence author)
46. Zhang Y, Yuan ZY*, Ge H, Ren Y. Effects of long-term ouabain treatment on blood pressure, sodium excretion, and renal dopamine D1 receptor levels in rats. J Comp Physiol B. 2010;180(1):117-24. [ Scientific Impact Factor = 2.827 ] (Correspondence author)
47. Zhang RY, Yuan ZY*. Ouabain reduces dopamine-inhibited renal Na+-K+-ATPase activity in cells. Clinical Experimental Pharmacology Physiology 2009 Nov 19. [Epub ahead of print] [ Scientific Impact Factor = 2.967 ] (Correspondence author)
48. Zhao Y, Yuan ZY* Liu Y, et al. Activation of Cannabinoid-2 Receptor Ameliorates Atherosclerosis Associated with Suppression of Adhesion Molecules. J Cardiovasc Pharmacol. 2010 Jan 9. [Epub ahead of print] PMID: 20075743. [ Scientific Impact Factor = 2.023 ] (Correspondence author)
49. Xue JH; Yuan ZY*; Wu Y; et al. High Glucose Promotes Intracellular Lipid Accumulation by Impairing the Balance between CD36 and ATP-Binding Cassette Transporter G1 in Vascular Smooth Muscle Cells. Circulation 2008: 118 (18 ): S567-S567. (Correspondence author)
50. Okabe TA, Hattori M, Yuan Z, Kishimoto C. L-arginine ameliorates experimental autoimmune myocarditis by maintaining extracellular matrix and reducing cytotoxic activity of lymphocytes. Int J Exp Pathol. 2008;89(5):382-388.
51. Kishimoto C, Okabe TA, Hattori M, Yuan Z. Naloxone, an opiate receptor antagonist, ameliorates acute experimental autoimmune myocarditis by reducing cytotoxic activities. J Cardiovasc Pharmacol. 2008;52(5):445-51.
52. Yuan ZY*, Liu Y, Liu Y, et al. PPARgamma gene C161T substitution is associated with reduced risk of coronary artery disease and decreased proinflammatory cytokine expression. Am Heart J. 2007;154(4):718-24. (Correspondence author)
53. Kishimoto C, Shioji K, Yuan ZY. FcγIIB and cardiovascular inflammatory disease. Circ Res. 2006;98(3):e26.
54. Yuan ZY*, Liu Y, Liu Y, et al. Cardioprotective effects of PPAR- activators in autoimmune myocarditis: Anti-inflammatory actions associated with NF- B blockade. Heart. 2005;91(9):1203-1208. (Correspondence author)
55. Yuan ZY, Nimata M, Okabe TA, et al. Olmesartan, a novel AT1 antagonist, suppresses cytotoxic myocardial injury in autoimmune heart failure. Am J Physiol Heart Circ Physiol. 2005; 289(3): H1147-52.
56. Nimata M, Okabe TA, Yuan ZY, Shioji K, Kishimoto C. MCI-186 (edaravone), a novel free radical scavenger, protects against acute autoimmune myocarditis in rats. Am J Physiol Heart Circ Physiol. 2005;289(6):H2514-8.
57. Yuan ZY, Shioji K, Nimata M, et al. Cardioprotective effects of carvedilol on acute autoimmune myocarditis. Mol Cell Biochem. 2004;259:223-227.
58. Yuan ZY*, Liu Y, Liu Y, et al. Peroxisome Proliferator-Activated Receptor-gamma Ligands Ameliorate Experimental Autoimmune Myocarditis Associated with Inhibition of Self-Sensitive T Cells. J Cardiovasc Pharmacol. 2004;43(6):868-875. [ Scientific Impact Factor = 2.023 ] (Correspondence author)
59. Yuan ZY, Shioji K, Kihara Y, et al. Cardioprotective effects of carvedilol on acute autoimmune myocarditis: anti-inflammatory effects associated with antioxidant property. Am J Physiol. 2004; 286(1): 83-90.
60. Yuan ZY*, Liu Y, Liu Y, et al. PPAR-γ ligands inhibit the expression of inflammatory cytokines and attenuate autoimmune myocarditis. Chin Med J 2004;117( 8):1253-1255. (Correspondence author)
61. Nimata M, Yuan Z, Kishimoto C, et al. Beneficial effects of olmesartan, a novel angiotensin II receptor type 1 antagonist, upon acute autoimmune myocarditis. Mol Cell Biochem. 2004; 259: 217-222.
62. Shioji K, Yuan Z, Kita T, et al. Immunoglobulin Treatment Suppressed Adoptively Transferred Autoimmune Myocarditis in Severe Combined Immunodeficient (SCID) Mice. Am J Physiol Heart Circ Physiol. 2004, 287(2): H2619-25.
63. Yao QH, Wang DQ, Cui CC, Yuan ZY. Curcumin ameliorates left ventricular function in rabbits with pressure overload: Inhibition of the remodeling of the left ventricular collagen network associated with suppression of myocardial tumor necrosis factor-alpha and matrix metalloproteinase-2 expression. Biol Pharmaceu Bull 2004;27 (2): 198-202.
64. Yuan ZY*, Liu Y, Liu Y, et al. Peroxisome proliferation-activated receptor-g ligands ameliorate experimental autoimmune myocarditis. Cardiovasc Res. 2003; 57: 392-401. (Correspondence author)
65. Yuan ZY, Kishimoto C, Yokode M. Immunoglobulin suppresses atherosclerosis in apoprotein E deficient mice via the Fc receptor. Am J Physiol. 2003; 285(2):899-906.
66. Yuan ZY, Kishimoto C, Shioji K, et al. Temocapril ameliorates autoimmune myocarditis by upregulating cardiomyocyte thioredoxin expression. Mol Cell Biochem. 2003; 248 :185-192.
67. Yuan ZY, Shioji K, Kishimoto C, et al. Immunohistological analyses of myocardial infiltrating cells in various animal models of myocarditis. Exp Clin Cardiol,2003;8 (1):13-16.
68. Yuan ZY, Kishimoto C, Shioji K. Beneficial effects of low-dose benidipine in acute autoimmune myocarditis. Circ J. 2003 ; 67(6): 545-550.
69. Kishimoto C, Shioji K, Yuan Z, et al. Therapy with immunoglobulin ameliorates giant cell myocarditis in rats. Pediatric Res 2003; 53(1): 101.
70. Yuan ZY, Kishimoto C, Yodoi, J, et al. Temocapril ameliorates autoimmune giant cell myocarditis in rats associated with upregulation of thioredoxin expression. Cardiovasc Res. 2002; 55: 320- 328.
71. Yuan ZY, Kishimoto C, Shioji K, et al. Fc portion of immunoglobulin suppresses atherosclerosis in apo E knockout mice. A anti-inflammatory action associated with anti-self-immune. Circulation 2002; 106(19):s119.
72. Shioji K, Kishimoto C, Nakamura H, Masutani H, Yuan Z, Oka S, Yodoi J. Thioredoxin-1 transgenic mice attenuates adriamyocin-induced cardiotoxicity; a novel redox modulating therapy against adriamyocin-induced cardiotoxicity. Circulation. 2002;106:1435-1439.
73. Shioji K, Kishimoto C, Yuan Z, et al. Immunoglobulin suppressed adoptively transferred autoimmune myocarditis in severe combined immunodeficient mice: A novel suppressive effect of immunoglobulin on self-reactive T cells. Circulation 2002; 106(suppl II):198.
74. Shioji K, Kishimoto C, Yuan Z, et al. Overexpression of thioredoxin in TRX transgenic mice attenuates adriamyocin-induced cardiotoxicity. Circulation 2002;106 (suppl II):50.
