神经细胞代谢异常与疾病.
主持国家和省级等课题9项,总经费200余万元
1.国家自然科学基金-面上基金 81671184 2017.01-2020.12 57万
2.国家自然科学基金-面上基金 81471110 2015.01-2018.12 70万
3.国家自然科学基金-青年基金 81100764 2012.01-2014.12 22万
4.陕西省青年科技新星配套 2015KJXX-49 2016.01-2017.12 10万
5.总后优秀青年科技人才扶持对象配套 2015.01-2017.12 10万
6.陕西省外专局留学回国人员启动经费 2016.01-2017.12 2万
7.第四军医大学青年英才资助计划 2011.01-2013.12 3万
8.中国博士后基金特别资助 2015T81094 2015.01-2017.12 30万
9.中国博士后基金面上资助 2014M562599 2014.01-2016.12 10万
(注:博士后课题军队1:1配套,所列经费为总额)
1. Li Y#,*, Yin A#, Sun X#, Zhang M#, Zhang J, Wang P, Xie R, Li W, Fan Z, Zhu Y, Wang H, Dong H, Wu S, Xiong L*. Deficiency of tumor suppressor NDRG2 leads to attention deficit and hyperactive behavior.J Clin Invest. 2017 Oct 127(12):4270-4284 (IF: 13.25; 第一作者/共同通讯作者,Highlight文章, F1000推荐文章)
2. Li Y#, Liu CH#, Hou WG#, Li Y, Ma J, Lin KF, Situ ZQ, Xiong LZ, Li SQ* and Yao LB*. Retrograde Ductal Administration of the Adenovirus-mediated NDRG2 Gene Leads to Improved Sialaden Hypofunction in Estrogen-deficient Rats. Mol Ther. 2014 May;22(5):908-18 (IF: 6.43; 第一作者)
3. Li Y#,*, Li SQ#, Qin XY#, Hou WG, Dong HL, Yao LB and Xiong LZ*. The pleiotropic roles of sphingolipid signaling in autophagy. Cell Death and Disease. 2014 May 22;5:e1245 (IF: 5.18; 第一作者/共同通讯作者)
4. Li Y#, Yang JD#, Li SQ#, Zhang J, Zheng J, Hou WG, Zhao HD, Guo YY, Liu XP, Dou KF, Situ ZQ* and Yao LB*. N-Myc downstream-regulated gene 2, a novel estrogen-targeted gene is involved in the regulation of NA+/K+-ATPase. J Biol Chem. 2011, 286(37):32289-32299 (IF: 5.33; 第一作者)
5. Ma J#, Liu WC#, Guo H#, Li SQ, Cao W, Du XL, Lei SX, Hou WG, Xiong LZ, Yao LB, Nanlin Li* and Li Y*. N-myc downstream-regulated gene 2 expression is associated with glucose transport and correlated with prognosis in breast carcinoma. Breast Cancer Res. 2014 Mar 18;16(2):R27 (IF: 5.87; 通讯作者,封面文章)
6. Lei S#, Yang J#, Chen C#, Sun J, Yang L, Tang H, Yang T, Chen A, Zhao H, Li Y*, Du X*. FLIPL is critical for aerobic glycolysis in hepatocellular carcinoma. J Exp Clin Cancer Res. 2016 May 13;35(1):79. (IF: 5.19; 共同通讯作者)
7. Yin A#, Wang C#, Sun J#, Gao J, Tao L, Du X, Zhao H, Yang J*, Li Y*. Overexpression of NDRG2 Increases Iodine Uptake and Inhibits Thyroid Carcinoma Cell Growth In Situ and In Vivo. Oncol Res. 2016;23(1-2):43-51 (IF: 1.74; 通讯作者)
8. Lin K#, Yin A, Yao L, Li Y*. N-myc downstream-regulated gene 2 in the nervous system: from expression pattern to function. Acta Biochim Biophys Sin. 2015,47(10):761-6 (IF: 2.12; 通讯作者)
9. Li Y#, Liu JY, Liu XP, Xing KF, Wang Y, Li FY, Yao LB*. Resveratrol-induced cell inhibition of growth and apoptosis in MCF7 human breast cancer cells are associated with modulation of phosphorylated Akt and caspase-9. Appl Biochem Biotech. 2006,135(3):181-192 (IF: 1.89; 第一作者)
10. Li Y#, Li SQ#, Han YH, Liu JY, Zhang J, Li FY, Wang Y, Liu XP, Yao LB*. Calebin-A Induces Apoptosis and Modulates MAPK family activity in drug-resistant human gastric cancer cells. Eur J Pharmacol. 2008;591:252-258 (IF: 2.59; 第一作者)
11. Yang JD#, Zheng J#, Wu L#, Shi M#, Zhang HT, Wang X, Xia N, Wang DS, Liu XP, Yao LB, Li Y* and Dou KF*. NDRG2 Ameliorates Hepatic Fibrosis by Inhibiting the TGF-β1/Smad Pathway and Altering the MMP2/TIMP2 Ratio in Rats. PLoS ONE. 2011;6(11):e27710 (IF: 4.09; 共同通讯作者)
12. Yang JD#, Li Y#, Wu L#, Zhang ZX, Han TL, Guo H, Jiang N, Tao KS, Ti ZY, Liu XP, Yao LB* and Dou KF*. NDRG2 in rat liver regeneration: Role in proliferation and apoptosis. Wound Repair Regen. 2010;18:524-531 (IF: 3.44; 共同第一作者)
13. Zheng J#, Li Y#, Yang JD#, Liu qiang#, Yao LB* and Liu WC*. NDRG2 inhibits hepatocellular carcinoma adhesion, migration and invasion by regulating CD24 expression. BMC Cancer. 2011, 11:251 (IF: 3.01; 共同第一作者)
14. Ma YL#, Qin P#, Li Y#, Shen L, Wang SQ, Dong HL, Hou WG* and Xiong LZ*. The effects of different doses of estradiol (E2) on cerebral ischemia in an in vitro model of oxygen and glucose deprivation and reperfusion and in a rat model of middle carotid artery occlusion. BMC Neurosci. 2013 Oct 9;14:118 (IF: 3.00; 共同第一作者)
15. Hou WG#, Hu J#, Li Y#, Zhao J, Li Zh, Liu XP, Yao LB and Zhang YQ*. Altered Expression of NDRG2 in the Testes of Experimental Rat Model of Cryptorchidism. Urology. 2010;75(4):985-991 (IF: 2.33; 共同第一作者)
16. Zheng J#, Liu Q#, Li Y#, Yang JD, Ma J, Yu F, Shi H, Ren Q, Zhang R, Zhang J, Xue Y, Tao YR, Jiang N, Guo H, Yao LB* and Liu WC*. NDRG2 Expression Regulates CD24 and Metastatic Potential of Breast Cancer Cells. Asian Pac J Cancer Prev. 2010;11(6):1817-21 (IF: 1.24; 共同第一作者)
17. 《精编分子生物学实验技术》 世界图书出版社 2017 主编
18. 《分子生物学实用实验技术》 第四军医大学出版社 2011 主编
19. 《细胞与分子生物学常用实验技术》第四军医大学出版社 2009 主编
授权实用新型专利3项:
1.一种动物唾液采集装置 专利号:ZL201120164444.0 排名第一
2.记忆型绷带 专利号:ZL201620268288.5 排名第一
3.一种实验室鼠笼 专利号:ZL201621295286.1排名第一
4.申请发明专利1项:多肽及其用于制备治疗缺血性脑卒中药物的应用申请号:201610284885.1 排名第一