建立了我国大骨节病疾病生物资源库，重点研究大骨节病软骨细胞分化、细胞凋亡、差异表达基因和蛋白、大骨节病早期诊断与疾病标志物、小麦喷硒防治大骨节病、透明质酸钠膝关节注射改善大骨节病功能障碍等。
2001年享受国务院特殊津贴专家，现兼任中华医学会地方病分会委员副主任委员暨大骨节病组组长、国家卫生标准委员地方病专业委员会副主任委员、卫生部疾病控制专家委员会地方病专业委员会委员、《国外医学地理分册》杂志主编，《中华地方病学》、《中国地方病防治》杂志副主编等学术职务。《Osteoarthritis and Cartilage》、《Journal of Pathology》、《Journal of Rheumatology》等杂志审稿人。国家自然科学基金项目二审、中华医学科技奖、陕西省科学技术进步奖等的评审专家。
发表论文286篇，其中SCI收录论文96篇，二篇被本领域著名杂志《Arthritis & Rheumatism》、《Proteomics》选为封面论文，一篇论文被推荐为“F1000论文”；获陕西省科技进步一(第一获奖人)、二、三等奖, 解放军总后勤部科学技术进步二等奖、西安市科技进步二等奖和陕西省高等院校科技进步奖等10余项，获国家发明专利1项。
主编《软骨分子生物学与临床应用》、《地方病分子生物学基础与应用》论著，参编全国高等学校教材供8年制及7年制的《预防医学》（第二、三版）、《中国遗传及地方性疾病资源谱》英文版中“大骨节病”、《地方病名词解释》等8部论著，培养博、硕士研究生和留学生122名。
以第一作者和通讯作者发表的部分学术论著
[1] Guo X, Ma WJ, Zhang F, Ren FL, Qu CJ, Lammi MJ. Recent advances in the research of an endemic osteochondropathy in China: Kashin-Beck disease. Osteoarthritis and Cartilage, 22(11):1774-1783. 2014
[2] Zhang F, Wen Y, Guo X*, Zhang YG, Wang X, Yang TL, Shen H, Chen XD, Tian Q, Deng HW. Genome-Wide Association Study Identifies ITPR2 as a Susceptibility Gene for Kashin-Beck Disease in Han Chinese. Arthritis & Rheumatology, 2015；67(1):176-181.
[3] Yujie Ning, Xi Wang, Sen Wang, Feng Zhang, Lianhe Zhang, Yanxia Lei, Xiong Guo*. Is It the Appropriate Time to Stop Applying Selenium Enriched Salt in Kashin-Beck Disease Areas in China?[J]. Nutrients, 2015, 7(8): 6195-6212.
[4] Xi Wang, Yujie Ning, Feng Zhang, Fangfang Yu, Wuhong Tan, Yanxia Lei, Cuiyan Wu, Jingjing Zheng,
[5] Sen Wang, Hanjie Yu, Zheng Li, Mikko J. Lammi, Xiong Guo*. Gene Expression Signature in Endemic Osteoarthritis by Microarray Analysis[J]. International journal of molecular sciences, 2015, 16(5): 11465-11481.
[6] Wang X, Ning Y, Tan W, Yu H, Li Z, Guo X*. Population-based comparative analysis of differentially expressed genes between Kashin-Beck disease grades I and II. Scand J Rheumatol, 2016, 45(3):230-235.
[7] Yu FF, Xia CT, Fang H, Wang DM, Guo X*. Reliability and validation of the joint dysfunction index as a new assessment instrument for therapeutic efficacy for Kashin-Beck disease. Clin Rheumatol, 2016, 35(11):2815-2821.
[8] Yu FF, Liu H, Guo X*. Integrative Multivariate Logistic Regression Analysis of Risk Factors for Kashin-Beck disease. Biol Trace Elem Res, 2016, 174(2):274-279.
[9] Yang L, Zhao GH, Liu H, Wang X, Guo X*, Lammi MJ. Field synopsis and meta-analyses of genetic epidemiological evidence for Kashin-Beck disease, an endemic osteoarthropathy in China. Mol Genet Genomics, 2016, 291(5):1823-1833.
[10] Yang L, Liu H, Guo X*, Lammi MJ. The potential biochemical markers of Kashin-Beck disease: a meta-analysis. Biomarkers, 2016, 21(7):633-638.
[11] Lin X, Guo X*. Advances in Biosensors, Chemosensors and Assays for the Determination of Fusarium Mycotoxins. Toxins, 2016, 8(6): 161-168.
[12] Yang L, Zhao GH, Wang X, Wang YT, Lin XL, Yu FF, Goldring MB, Guo X*, Lammi MJ. Cellular responses to T-2 toxin and/ or deoxynivalenol that induce cartilage damage are not specific to chondrocytes. Sci Rep, 2017, 7(1): 2231-2237.
[13] Yang L, Zhang JP, Zhao GH, Wu CY, Ning YJ, Wang X, Lammi MJ, Guo X*. Gene expression profiles and molecular mechanism of cultured human chondrocytes’ exposure to T-2 toxin and deoxynivalenol. Toxicon, 2017, 140: 38-44.
[14] Yu FF, Ping ZG, Yao C, Wang ZW, Wang FQ, Guo X*. Evaluation of sensitivity and specificity on new clinical diagnosis and classification criterion for endemic osteoarthritis in China: Kashin-Beck disease. Biomed Environ Sci, 2017, 30(2): 150-155.
[15] Yu FF, Lin XL, Wang X, Liu H, Yang L, Goldring MB, Lammi MJ, Guo X*. Selenium promoted metabolic activation of T-2 toxin in the cultured human chondrocytes. J Trace Elem Med Biol, 2017, 44:218-224.
[16] Wang X, Ning YJ, Zhang P, Yang L, Wang YT, Guo X*, Chondrocytes Damage Induced by T-2 Toxin via Wnt/β-Catenin Signaling Pathway is Involved in the pathogenesis of an Endemic Osteochondropathy, Kashin-Beck Disease. Exp Cell Res, 2017, 361(1):141-148
[17] Wang X, Ning YJ, Yang L, Yu FF, Guo X*. Zinc: the Other Suspected Environmental Factor in Kashin-Beck Disease in Addition to Selenium. Biol Trace Elem Res, 2017, 179(2): 178–184.
[18] Wang X, Ning YJ, Zhou B, Yang L, Wang YT, Guo X*, Integrated bioinformatics analysis of the osteoarthritis associated microRNA expression signature. Mol Med Rep, 2018, 17(1): 1833-1838.
[19] Wang X, Ning YJ, Yang L, Liu H, Wu CY, Wang S, Guo X*, Diagnostic value of circulating microRNAs for osteosarcoma in Asian populations: a meta-analysis. Clin Exp Med, 2017, 17(2):175-183.
[20] Zhang F, Wen Y, Guo X*, Zhang Y, Wang S, Yang T, Shen H, Chen X, Tan L, Tian Q, Deng HW. Genome-wide pathway-based association study implicates complement system in the development of Kashin-Beck disease in Han Chinese. Bone, 71:36-41. 2015
[21] Zhang F, Wen Y, Guo X*, Zhang YG, Wang X, Yang TL, Shen H, Chen XD, Tian Q, Deng HW. Genome-Wide Association Study Identifies ITPR2 as a Susceptibility Gene for Kashin-Beck Disease in Han Chinese. Arthritis & Rheumatology, 67(1):176-181. 2015
[22] Zhang F, Wen Y, Guo X*, Yang TL, Shen H, Chen XD, Tan LJ, Tian Q, Deng HW. Trans-omics pathway analysis suggests that eQTLs contribute to chondrocyte apoptosis of Kashin-Beck disease through regulating apoptosis pathway expression. Gene, 553(2):166-169. 2014
[23] Zhang F, Wen Y, Guo X*. CRISPR/Cas9 for genome editing: progress, implications and challenges. Hum Mol Genet, 23(R1):R40-46. 2014
[24] Zhang F, Guo X*, Zhang YP, Wen Y, Wang WZ, Wang S, Yang TL, Shen H, Chen XD, Tian Q, Tan LJ, Deng HW. Genome-wide copy number variation study and gene expression analysis identify ABI3BP as a susceptibility gene for Kashin-Beck disease. Human Genetics, 133(6):793-799. 2014
[25] Yu FF, Xia CT, Fang H, Han J, Younus MI, Guo X*. Evaluation of the therapeutic effect of treatment with intra-articular hyaluronic acid in knees for Kashin-Beck disease: a meta-analysis. Osteoarthritis Cartilage, 22(6):718-725. 2014
[26] Xia CT, Yu FF, Ren FL, Fang H, Guo X*. Hyaluronic acid and glucosamine sulfate for adult Kashin-Beck disease: a cluster-randomized, placebo-controlled study. Clin Rheumatol, 2014
[27] Wu SX, Wang WZ, Zhang F, Wu CY, Dennis BS, Qu CJ, Bai YD, Guo X*. Expression profiles of genes involved in apoptosis and selenium metabolism in articular cartilage of patients with Kashin-Beck osteoarthritis. Gene, 535(2):124-130. 2014
[28] Wu CY, Lei RH, Tiainen M, Wu SX, Zhang Q, Pei FX, Guo X*. Disordered glycometabolism. involved in pathogenesis of Kashin-Beck disease, an endemic osteoarthritis in China. Experimental Cell Research, 326(2):240-250. 2014
[29] Wu C, Zheng J, Yao X, Shan H, Li Y, Xu P, Guo X*. Defective autophagy in chondrocytes with Kashin-Beck disease but higher than osteoarthritis. Osteoarthritis and Cartilage, 22(11):1936-1946. 2014
[30] Wen Y, Zhang F, Li CY, He SL, Tan WH, Lei YX, Zhang Q, Yu HJ, Zheng JJ, Guo X*. Gene Expression Analysis Suggests Bone Development-Related Genes GDF5 and DIO2 Are Involved in the Development of Kashin-Beck Disease in Children Rather than Adults. Plos One, 9(7): e103618. 2014
[31] Ma WJ, Guo X*, Yu YX, Gao ZQ. Cytoskeleton Remodeling and Oxidative Stress Description in Morphologic Changes of Chondrocyte in Kashin-Beck Disease. Ultrastructural Pathology, 38(6):406-412. 2014
[32] Liu JT, Wang LL, Guo X*, Pang QJ, Wu SX, Wu CY, Xu P, Bai YD. The Role of Mitochondria in T-2 Toxin-Induced Human Chondrocytes Apoptosis. Plos One, 9(9): e108394.2014
[33] He S, Tan W, Wang S, Wu C, Wang P, Wang B, Su X, Zhao J, Guo X*, Xiang Y. Genome-wide study reveals an important role of spontaneous autoimmunity, cardiomyocyte differentiation defect and anti-angiogenic activities in gender-specific gene expression in Keshan disease. Chin Med J (Engl), 127(1):72-78. 2014
[34] Zheng JJ, Wu CY, Ma WJ, Zhang YT, Hou TZ, Xu HH, Wu SX, Yao X, Guo X*. Abnormal expression of chondroitin sulphate N-acetylgalactosaminyltransferase 1 and Hapln-1 in cartilage with Kashin-Beck disease and primary osteoarthritis. International Orthopaedics, 37(10):2051-2059. 2013
[35] Zhang F, Liang JL, Guo X*, Zhang YG, Wen Y, Li Q, Zhang ZT, Ma WJ, Dai LL, Liu XZ, Yang L, Wang J. Exome Sequencing and Functional Analysis Identifies a Novel Mutation in EXT1 Gene That Causes Multiple Osteochondromas. Plos One, 8(8): e72316. 2013
[36] Zhang F, Guo X*, Duan C, Wu S, Yu H, Lammi M. Identification of differentially expressed genes and pathways between primary osteoarthritis and endemic osteoarthritis (Kashin-Beck disease). Scandinavian Journal of Rheumatology, 42(1):71-79. 2013
[37] Wang X, Wang S, He SL, Zhang F, Tan WH, Lei YX, Yu HJ, Li Z, Ning YJ, Xiang YZ, Guo X*. Comparing gene expression profiles of Kashin-Beck and Keshan diseases occurring within the same endemic areas of China. Science China-Life Sciences, 56(9):797-803. 2013
[38] Wang S, Duan C, Zhang F, Ma WJ, Guo X*. Regulatory gene networks and signaling pathways from primary osteoarthritis and Kashin-Beck disease, an endemic osteoarthritis, identified by three analysis software. Gene, 512(1):89-96. 2013
[39] Ning YJ, Wang X, Ren L, Guo X*. Effects of Dietary Factors on Selenium Levels of Children to Prevent Kashin-Beck Disease During a High-Prevalence Period in an Endemic Area: a Cohort Study. Biological Trace Element Research, 153(1-3):58-68. 2013
[40] He SL, Tan WH, Zhang ZT, Zhang F, Qu CJ, Lei YX, Zhu YH, Yu HJ, Xiang YZ, Guo X*. Mitochondrial-related gene expression profiles suggest an important role of PGC-1alpha in the compensatory mechanism of endemic dilated cardiomyopathy. Experimental Cell Research, 319(17):2604-2616. 2013
[41] Han J, Guo X*, Tan WH, Zhang F, Liu JT, Wang WH, Xu P, Lammi MJ. The expression of p-ATF2 involved in the chondeocytes apoptosis of an endemic osteoarthritis, Kashin-Beck disease. Bmc Musculoskeletal Disorders, 14:209-219. 2013
[42] Han J, Guo X*. Down-regulation of ATF2 in the inhibition of T-2-toxin-induced chondrocyte apoptosis by selenium chondroitin sulfate nanoparticles. Journal of Nanoparticle Research, 15(12):2037-2042. 2013
[43] Cao CX, Zhang YG, Wu SX, Younas MI, Guo X*. Association of clinical features of bone and joint lesions between children and parents with Kashin-Beck disease in Northwest China. Clinical Rheumatology, 32(9):1309-1316. 2013
[44] Zhao QM, Guo X*, Lai JH, Tan WH, Wang WZ, Dang XQ. Association of TNF-alpha and Fas gene promoter polymorphism with the risk of Kashin-Beck disease in Northwest Chinese population. Clinical Rheumatology, 31(7):1051-1057. 2012
[45] Zhang F, Guo X*, Wang WZ, Wu SX, Ma WJ, Yan H. Expression profile analysis of mycotoxin-related genes in cartilage with endemic osteochondropathy Kashin-Beck disease. BMC Musculoskeletal Disorders, 13:130-136. 2012
[46] Wang S, Guo X*, Wu XM, Lammi MJ. Genome-Wide Gene Expression Analysis Suggests an Important Role of Suppressed Immunity in Pathogenesis of Kashin-Beck Disease. Plos One, 7(1): e28439.2012
[47] Wang S, Guo X*, Wang WZ, Wang S. Genome-wide study identifies the regulatory gene networks and signaling pathways from chondrocyte and peripheral blood monocyte of Kashin-Beck disease. Genes to Cells, 17(8):619-632. 2012
[48] Li CY, Wang WZ, Guo X*, Zhang F, Ma WJ, Zhang YG, Li YF, Bai YD, Lammi MJ. Pathways related to mitochondrial dysfunction in cartilage of endemic osteoarthritis patients in China. Science China-Life Sciences, 55(12):1057-1063. 2012
[49] Han J, Guo X*, Lei YX, Dennis BS, Wu SX, Wu CY. Synthesis and characterization of selenium-chondroitin sulfate nanoparticles. Carbohydrate Polymers, 90(1):122-126. 2012
[50] Gao ZQ, Guo X*, Duan C, Ma W, Xu P, Wang W, Chen JC. Altered Aggrecan Synthesis and Collagen Expression Profiles in Chondrocytes from Patients with Kashin-Beck Disease and Osteoarthritis. Journal of International Medical Research, 40(4):1325-1334. 2012
[51] Fang H, Guo X*, Farooq U, Xia C, Dong R. Development and validation of a quality of life instrument for Kashin-Beck disease: an endemic osteoarthritis in China. Osteoarthritis and Cartilage, 20(7):630-637. 2012
[52] Zhang F, Guo X*, Wang WZ, Yan H, Li CY. Genome-Wide Gene Expression Analysis Suggests an Important Role of Hypoxia in the Pathogenesis of Endemic Osteochondropathy Kashin-Beck Disease. Plos One, 6(7): 229-233. 2011
[53] Ma WJ, Guo X*, Liu JT, Liu RY, Hu JW, Sun AG, Yu YX, Lammi MJ. Proteomic changes in articular cartilage of human endemic osteoarthritis in China. Proteomics, 11(14):2881-2890. 2011
[54] Lu AL, Guo X*, Aisha MMT, Shi XW, Zhang YZ, Zhang YY. Kashin-Beck disease and Sayiwak disease in China: Prevalence and a comparison of the clinical manifestations, familial aggregation, and heritability. Bone, 48(2):347-353. 2011
[55] Farooq U, Guo X *, Chuang LH, Zhang GH. Measuring Health Related Quality of Life in Kashin-Beck Disease, a Special Osteochondropathy in China, Using Eq-5d. Rheumatology, 50:65-65. 2011
[56] Farooq U, Guo X*, Chuang LH, Fang H, Zhuang GH, Xia CT. Measuring health-related quality of life in Kashin-Beck disease using EQ-5D. Quality of Life Research, 20(3):425-429. 2011
[57] Shi XW, Guo X*, Ren FL, Li J, Wu XM. The Effect of Short Tandem Repeat Loci and Low Selenium Levels on Endemic Osteoarthritis in China. Journal of Bone and Joint Surgery-American Volume, 92A(1):72-80. 2010
[58] Shi XW, Guo X*, Lv AL, Kang L, Zhou YL, Zhang YZ, Wu XM, Bai YD. Heritability estimates and linkage analysis of 23 short tandem repeat loci on chromosomes 2, 11, and 12 in an endemic osteochondropathy in China. Scandinavian Journal of Rheumatology, 39(3):259-265. 2010
[59] Liu JT, Guo X*, Ma WJ, Zhang YG, Xu P, Yao JF, Bai YD. Mitochondrial function is altered in articular chondrocytes of an endemic osteoarthritis, Kashin-Beck disease. Osteoarthritis and Cartilage, 18(9):1218-1226. 2010
[60] Duan C, Guo X*, Zhang XD, Yu HJ, Yan H, Gao Y, Ma WJ, Gao ZQ, Xu P, Lammi M. Comparative Analysis of Gene Expression Profiles Between Primary Knee Osteoarthritis and an Osteoarthritis Endemic to Northwestern China, Kashin-Beck Disease. Arthritis and Rheumatism, 62(3):771-780. 2010
[61] Du JQ, Wu XM, Zhang HQ, Wang SA, Tan WH, Guo X*. Mass spectrometry-based proteomic analysis of Kashin-Beck disease. Molecular Medicine Reports, 3(5):821-824. 2010
[62] Zhang YZ, Guo X*, Ping ZG, Yu M, Shi XW, Lv AL, Wang FQ, Wang ZW. Main Source of Drinking Water and Familial Aggregation of Kashin-Beck Disease: A Population Based on Case-Control Family Study. Annals of Epidemiology, 19(8):560-566. 2009
[63] Wang WZ, Guo X*, Duan C, Ma WJ, Zhang YG, Xu P, Gao ZQ, Wang ZF, Yan H, Zhang YF, Yu YX, Chen JC, Lammi MJ. Comparative analysis of gene expression profiles between the normal human cartilage and the one with endemic osteoarthritis. Osteoarthritis and Cartilage, 17(1):83-90. 2009
[64] Wang WZ, Guo X*, Chen JC, Xu P, Lammi MJ. Morphology and phenotype expression of types I, II, III, and X collagen and MMP-13 of chondrocytes cultured from articular cartilage of Kashin-Beck Disease. Journal of Rheumatology, 35(4):696-702. 2008
[65] Wang S, Guo X*, Tan WH, Geng D, Deng BP, Wang CE, Qu X. Detection of serum proteomic changes and discovery of serum biomarkers for Kashin-Beck disease using surface-enhanced laser desorption ionization mass spectrometry (SELDI-TOF MS). Journal of Bone and Mineral Metabolism, 26(4):385-393. 2008
[66] Ren FL, Guo X*, Zhang RJ, Wang Sh J, Zuo H, Zhang ZT, Geng D, Yu Y, Su M. Effects of selenium and iodine deficiency on bone, cartilage growth plate and chondrocyte differentiation in two generations of rats. Osteoarthritis Cartilage, 15(10):1171-1177. 2007
[67] Wang SJ, Guo X*, Zuo H, Zhang YG, Xu P, Ping ZG, Zhang Z, Geng D. Chondrocyte apoptosis and expression of Bcl-2, Bax, Fas, and iNOS in articular cartilage in patients with Kashin-Beck disease. J Rheumatol, 33(3):615-619. 2006
[68] Guo X, Zuo H, Cao CX, Zhang Y, Geng D, Zhang ZT, Zhang YG, von der Mark K, von der Mark H. Abnormal expression of Col X, PTHrP, TGF-beta, bFGF, and VEGF in cartilage with Kashin-Beck disease. Journal of Bone and Mineral Metabolism, 24(4):319-328. 2006
[69] Zhang YG, Guo X*, Xu P, Kang LL, Li J. Bone mesenchymal stem cells transplanted into rabbit intervertebral discs can increase proteoglycans. Clinical Orthopaedics and Related Research, (430):219-226. 2005
[70] Xiong G. Diagnostic, clinical and radiological characteristics of Kashin-Beck disease in Shaanxi Province, PR China. Int Orthop, 25(3):147-150. 2001
[71] Chen JH , Chu YL , Yang ZHT, Cao JL , Shi ZHL, Li SY , Guo X, Wang ZHL. T-2 toxin induces apoptosis and selenium partly blocks T-2 induced apoptosis in chondrocytes through modulation of the Bax/Bcl-2 ratio. Food and Chemical Toxicology, 44(4):567-673. 2006
[72] Xu P, Zeng LX, G.N.Schlauzer, Guo X*. Selenium, boron, and germanium deficiency in the etiology of Kashin-Beck disease. Biological Trace Element Research, 77(3):193-197. 2000
[73] Wang SHJ，Guo X*，Zuo H, Xu P, Ping ZHG, Zhang YG, Zhang ZT, Geng D. Chondrocyte Apoptosis in Articular Cartilage with Kashin-Beck Disease. Academic Journal of Xi'an Jiaotong University, 17(1):80-84. 2005
授权发明专利
韩晶，郭雄，张峰，马玮娟，武世勋，一种硫酸软骨素纳米硒及其制备方法，2013.7.10-2023.7.10，中国，ZL201110084034.X。
获得学术奖励
郭雄(1/11)，大骨节病分子发病机制及生物填充疗法的研究， 陕西省人民政府，2013年陕西省科学技术奖，(一等奖) ,省级，2013。（郭雄，任峰玲，许鹏，段琛，王爽，张银刚，王伟卓，史晓薇，马玮娟，张峰，平智广）
