吴捷，男，药理学教授，博士研究生和硕士研究生导师。1985年大学本科毕业于西安交通大学生物医学电子工程与仪器专业，获工学学士学位，同年留校任教至今。2003年获西安交通大学药理学硕士学位，2009年获西安交通大学药理学博士学位。2005年～2007年和2010年～2012年在日本滋贺医科大学呼吸循环内科学讲座和细胞生理学讲座进行博士后研究和工作，担任助理教授职务。研究方向为心血管药理学和心血管生理学，利用膜片钳和分子生物学方法研究神经递质、药物对心脏离子通道的分子调控机制及其与遗传性心律失常的关系。主持和参与多项国家自然科学基金、教育部国际合作与交流重点项目基金、陕西省中医管理局基金等课题研究。发表论文50多篇，第一作者及通讯作者SCI收录论文8篇 (累计影响因子42，单篇最高16.503)。获国家发明专利2项。常年与日本、美国、英国等国际一流心血管实验室进行科研协作，2015年荣获日本滋贺医科大学优秀研究者奖。2016年获陕西省科学技术奖第二等奖（第一获奖人）。
1.遗传性隐匿性1型长QT综合征分子机制研究（No.81470378；资助经费：73万元，2015.1-2018.12）
2.利用转基因表达心脏 Kv1.5钾离子通道研究新型房颤治疗药物（No.81273501；资助经费：70万元，2013.1-2016.12）
1. Wu J(通讯作者), Ding WG, Horie M. Molecular pathogenesis of long QT syndrome type 1 (review). J Arrhythm. 2016; 32:381.
2. 翟晓晨, 吴捷(通讯作者). 三七总皂苷对脑缺血/再灌注损伤保护机制的研究进展. 中国药学杂志. 2016; 151: 24-27.
3. 董超，高洁，翟晓晨，吴捷(通讯作者). Kv1.5钾离子通道阻滞剂的研究进展. 中国药理学与毒理学杂志. 2016; 30:1097-1101.
4. Wu J, Naiki N, Ding WG, Ohno S, Kato K, Zang WJ, Matsuura H, Horie M. A Molecular Mechanism for Adrenergic- induced Long QT Syndrome. J Am Coll Cardiol. 2014; 63(8): 819. (IF：16.503)
5. Zhou J, Ding WG,Makiyama T, Miyamoto A, Matsumoto Y, Kimura H, Tarutani Y, Zhao J, Wu J (通讯作者), Zang WJ, Matsuura H, Horie M. A novel HCN4 mutation, G1097W, is associated with atrioventricular block. Circ J. 2014; 78(4): 938. (IF：3.96)
6. Wu J, Ding WG,Zhao J,Zang WJ, Matsuura H,Horie M. Irbesartan mediated AT1 receptor blockade attenuates hyposmostic-induced enhancement of IKs current and prevents shortening of action potential duration in atrial myocytes. J Renin Angiotensin Aldosterone Syst. 2014;15: 341-347. (IF:2.4).
7. Wu J, Ding WG, Matsuura H, Horie M. Regulatory mechanisms underlying the modulation of GIRK1/GIRK4 heteromeric channels by P2Y receptors. Pflugers Arch. 2012; 464:625. (IF：4.87)
8. Nakajima T, Wu J (并列第一作者), Kaneko Y, Ashihara T, Ohno S, Irie T, Ding WG, Matsuura H, Kurabayashi M, Horie M. KCNE3 T4A as the genetic basis of brugada-pattern electrocardiogram. Circ J. 2012; 76: 2763. (IF：3.58)
9. Wu J, W Shimizu, W-G Ding, Ohno S, Toyoda F, Itoh H, W-J Zang, Miyamoto Y, Kamakura S, Matsuura H, Nademanee K, Brugada J, Brugada P, Brugada R, Vatta M, Towbin JA, Antzelevitch C, Horie M. KCNE2 Modulation of KV4.3 Current and its Potential Role in Fatal Rhythm Disorders. Heart Rhythm 2010; 7:199. (IF：5.05)
10. Wu J, Ding W-G, Matsuura H, Tsuji K, Zang W-J, Horie M. Inhibitory actions of the phosphatidylinositol 3-kinase inhibitor LY294002 on the human Kv1.5 channel. Br J Pharmacol. 2009; 156:377. (IF：5.20)
11.Itoh H, Crotti L, Aiba T, Spazzolini C,Denjoy I, Fressart V, Hayashi K, Nakajima T, Ohno S, Makiyama T, Wu J, Hasegawa K,Mastantuono E, Dagradi F, Pedrazzini M, Yamagishi M, Berthet M,Murakami Y, Shimizu W, Guicheney P, Schwartz PJ, Horie M. The genetics underlying acquired long QT syndrome: impact for genetic screening. Eur Heart J. 2016; 37:1456-1464. (IF：19.651)
12. Kato K, Makiyama Y, Wu J, Ding WG, Kimura H, Naiki N, et al. Cardiac Channelopathies Associated with Infantile Fatal Ventricular Arrhythmias: From the Cradle to the Bench. J Cardiovasc Electrophysiol. 2014; 25: 66. (IF：3.48)
13.Wang Q, Ohno S, Ding WG, Fukuyama M, Miyamoto A, Itoh H, Makiyama T, Wu J, et al. Phenotype variability in patients carrying KCNJ2 mutations. Cardiovasc Electrophysiol. 2014; 25:522. (IF：3.48)
14.Kimura H, Zhou J, Kawamura M, Itoh H, Mizusawa Y, Ding WG, Wu J,et al. Phenotype variability in patients carrying KCNJ2 mutations.Circ Cardiovasc Genet. 2012; 5: 344. (IF：6.73)
15.Li P, Ninomiya H, Kurata Y, Kato M, Miake J, Yamamoto Y, Igawa O,Nakai A, Higaki K, Toyoda F, Wu J, et al. Reciprocal control of hERG stability by Hsp70 and Hsc70 with implication for restoration of LQT2 mutant stability. Circ Res. 2011; 108: 458. (IF：11.86)
16.Gong YZ, Ding WG, Wu J, Tsuji K, Horie M, Matsuura H. Cinnamyl-3,4-dihydroxy-α-cyanocinnamate and nordihydroguaiaretic acid inhibit human Kv1.5 currents independently of lipoxygenase. Eur J Pharmacol. 2008; 600:18. (IF：2.79)
17.Lu J, Zhu SM, Zang WJ, Xu XL, Wu J, Horie M, et al. Protective mechanism of adenosine to the rat arterial endothelial dysfunction induced by hydrogen peroxide. Biol Pharm Bull. 2007; 30:1206. (IF：2.00)
18.Nagaoka I, Matsui K, Ueyama T, Kanemoto M, Wu J, Horie M, et al.A novel mutation of plakophilin-2 associated with arrhythmogenic right ventricular cardiomyopathy. Circ J. 2006; 70:933. (IF：3.58)
