杨维娜，医学博士，教授，博士研究生导师，国家自然科学基金函审专家，教育部学位论文评审专家，陕西省解剖学会理事。
研究方向
1.神经系统退行性疾病的发病机制及防治
2.神经胶质细胞与阿尔茨海默病
教育及工作简历
2000年本科毕业于西安交通大学临床医学专业，同年留校任教，历任形态中心、人体解剖与组织胚胎学系助教、讲师、副教授、教授。2004年获西安交通大学病理学与病理生理学专业硕士学位，2016年获西安交通大学人体解剖与组织胚胎学专业博士学位。2016年到2017年作为访问学者在美国哈佛大学医学院从事科研工作一年半。
主讲中英文解剖学课程10门，主编、参编教材16部，主持和参与教改项目15项，发表教学论文16篇，获西安交通大学第十九届本科教学成果二等奖。培养的研究生获陕西省第六届研究生创新成果优秀奖、西安交通大学“优秀留学生标兵”、国家奖学金、西安交通大学优秀硕士学位论文等奖项。指导的本科生获全国大学生基础医学创新研究“二等奖”和“铜奖”各1项（国家级）、获陕西省“挑战杯”大学生课外学术科技作品竞赛“二等奖”、西安交通大学本科生优秀毕业设计（论文）奖等。
科研项目
主持国家自然科学基金、陕西省自然科学基础研究计划项目、中国博士后科学基金特别资助、中国博士后科学基金面上一等资助、陕西省博士后科研项目面上一等资助、中央高校基本科研业务费、西安交通大学医学“基础-临床”融合创新项目、西安市神经免疫疾病创新转化重点实验室开放课题等项目9项。参与国家级和省部级科研项目6项。
科研论文（通讯作者）
1. Zikang Yang, Xiaoqian Peng, Xiao Zhang, Hongsong Guo, Zihao Li, Xiangyuan Wu, Mingtao Zhao, John Bosco Ruganzu, Congxuan Zhai, Shengfeng Ji,Weina Yang*. Tanshinone IIA promotes hippocampal neurogenesis in ApoE−/−mice through cAMP/PKA/CREB/BDNF signaling pathway.Mol. Neurobiol.2026,63:144.
2. Hongsong Guo, Xiaoqian Peng, Xiao Zhang, John Bosco Ruganzu, Xiangyuan Wu, Mingtao Zhao, Pengbo Yang, Shengfeng Ji,Weina Yang*. Insulin-like growth factor-1 enhances β-amyloid protein clearance in HMC3 microglia via low-density lipoprotein receptor-related protein 1-mediated pathway.Exp. Cell Res.2026,457:114920.
3. Xiaoqian Peng#, Zikang Yang#, Hongsong Guo, Xiangyuan Wu, John Bosco Ruganzu, Zhongzhong Liu, Songdi Wu*,Weina Yang*. TREM2 alleviates neuroinflammation and improves neurogenesis in ApoE−/−mice by regulating M1/M2 microglial polarization. Mol. Neurobiol.2026,63:105.
4. Mengke Wang, Baochen Zhang, Renhao Guo, Haiqin Wang, Di Wu, Xiaoqian Peng, Hongsong Guo, Jiawei Duan,Weina Yang*, Pengyu Ren*, Siyuan Zhang*. Restoration of autophagy-lysosomal function via transcranial focused ultrasound stimulation ameliorates β-amyloid pathology and cognitive deficits in an Alzheimer’s disease model. Ultrasonics.2026,165:108075.
5. Xiaoqian Peng, Hongsong Guo, Xiao Zhang, Xiangyuan Wu, John Bosco Ruganzu, Songdi Wu, Mingtao Zhao, Lei Li, Yang Yang, Shengfeng Ji,Weina Yang*, Pengyu Ren*. TREM2 promotes hippocampal neurogenesis through regulating microglial M2 polarization in APP/PS1 mice. Exp Neurol. 2025,388:115205.
6. Xiaoqian Peng, Hongsong Guo, Xiao Zhang, Zikang Yang, John Bosco Ruganzu, Zhuoyuan Yang, Xiangyuan Wu, Wei Bi, Shengfeng Ji,Weina Yang*.TREM2 inhibits tau hyperphosphorylation and neuronal apoptosis via the PI3K/Akt/GSK-3β signaling pathway in vivo and in vitro. Mol.Immunol.2023,60:2470-2485.
7. Xiaoqian Peng, Li Chen, Zijuan Wang, Yingying He, John Bosco Ruganzu, Hongsong Guo, Xiao Zhang, Shengfeng Ji, Liming Zheng,Weina Yang*. Tanshinone IIA regulates glycogen synthase kinase-3β-related signaling pathway and ameliorates memory impairment in APP/PS1 transgenic mice. Eur. J. Pharmacol. 2022,918:174772.
8. John Bosco Ruganzu, Xiaoqian Peng, Xiangyuan Wu, Quzhao Zheng, Bo Ding, Chengheng Lin, Hongsong Guo, Zikang Yang, Xiao Zhang,Weina Yang*. Downregulation of TREM2 expression exacerbates neuroinflammatory responses through TLR4-mediated MAPK signaling pathway in a transgenic mouse model of Alzheimer’s disease. Mol.Immunol.2022,142: 22-36.
9. John Bosco Ruganzu, Quzhao Zheng, Xiangyuan Wu, Yingying He, Xiaoqian Peng, Hui Jin, Jinsong Zhou, Ruiyang Ma, Shengfeng Ji, Yanbing Ma, Yihua Qian, Yang Wang,Weina Yang*. TREM2 overexpression rescues cognitive deficits in APP/PS1 transgenic mice by reducing neuroinflammation via the JAK/STAT/SOCS signaling pathway. Exp Neurol.2021,113506.
10. Bo Ding, Chengheng Lin,Qian Liu, Yingying He, John Bosco Ruganzu, Hui Jin, Xiaoqian Peng, Shengfeng Ji, Yanbing Ma,Weina Yang*. Tanshinone IIA attenuates neuroinflammation via inhibiting RAGE/NF-κB signaling pathway in vivo and in vitro. J. Neuroinflamm. 2020,17:302.
11. Yingying He, John Bosco Ruganzu, Quzhao Zheng, Xiangyuan Wu, Hui Jin, Xiaoqian Peng, Bo Ding, Chengheng Lin, Shengfeng Ji, Yanbing Ma,Weina Yang*. Silencing of LRP1 exacerbates inflammatory response via TLR4/NF-κB/MAPKs signaling pathways in APP/PS1 transgenic mice. Mol. Neurobiol. 2020,57:3727-3743.
12. Yingying He, John Bosco Ruganzu, Chengheng Lin, Bo Ding, Quzhao Zheng, Xiangyuan Wu, Ruiyang Ma, Qian Liu, Yang Wang, Hui Jin, Yihua Qian, Xiaoqian Peng, Shengfeng Ji, Liangliang Zhang,Weina Yang*, Xiaomei Lei*. Tanshinone IIA ameliorates cognitive deficits by inhibiting endoplasmic reticulum stress-induced apoptosis in APP/PS1 transgenic mice. Neurochem. Int. 2020,133: 104610.
13. Yingying He, John Bosco Ruganzu, Hui Jin, Xiaoqian Peng, Shengfeng Ji, Yanbing Ma, Liming Zheng,Weina Yang*. LRP1 knockdown aggravates Aβ1–42-stimulated microglial and astrocytic neuroinflammatory responses by modulating TLR4/NF-κB/MAPKs signaling pathways. Exp. Cell Res. 2020,394:112166.
14. Hui Jin, Xiaoqian Peng, Yingying He, John Bosco Ruganzu,Weina Yang*. Tanshinone IIA suppresses lipopolysaccharide-induced neuroinflammatory responses through NF-κB/MAPKs signaling pathways in human U87 astrocytoma cells. Brain Res. Bull. 2020,164: 136-145.
联系方式
电子邮箱：wn_yang@mail.xjtu.edu.cn
个人主页：http://gr.xjtu.edu.cn/web/wn_yang
