王维蓉


 

王维蓉,医学博士,副教授,博士生导师

研究领域或方向

1. 心血管疾病发生发展机制

2. 心血管疾病表观遗传学调控

3. 心血管疾病药物治疗

招收病理学与病理生理学专业的硕士和博士研究生。

招收药学专业硕士研究生。

招收与医学、药学、护理、生物医学等相关学科的推免生

工作简历

2009-2013,博士,药理学,西安交通大学

2013-2017,讲师,博士后,西安交通大学

2016-2017,访问学者,病理系,美国华盛顿大学

2017-至今,副教授、西安交通大学

2019-至今,博士生导师,西安交通大学

科研项目

先后主持国家及省部级、校级基金项目8项,其中主持国家自然科学基金2项,中国博士后基金特别资助1项,中国博士后面上项目1项,省部级基金4项。指导大学生创新实验项目6项及开放性实验2项。参与多项国家自然科学基金、省市及横向基金的研究。

1. 国家自然科学基金面上项目,组蛋白去乙酰化酶HDAC3去巴豆酰化修饰对动脉粥样硬化中EndMT的调控及机制,在研,主持。

2. 国家自然科学基金青年科学基金项目,miR-145通过SIRT1调控血管内膜增生过程中平滑肌细胞自噬的研究,已结题,主持。

学术科研

主要从事心血管疾病的发生机制及防治方面的研究,已经发表SCI论文50多篇,其中以第一或通讯作者发表SCI收录论文17篇,参与授权专利5项,参编教材专著5部。曾在美国华盛顿大学进行访学研究。

担任中国药理学会生化与分子药理学专业委员会委员、陕西省药理学会理事、陕西省药理学会生化与分子药理学专业委员会常务委员、中国药理学会抗炎免疫药理专业委员会青年委员等。现任《中国动脉硬化杂志》和《中国临床药理学与治疗学》青年编委,获得中国药理学会颁发的青年药理学工作者奖。

以第一/通讯作者发表SCI论文

  1. Li G, Shang C, Li Q, Chen L, Yue Z, Ren L, Yang J, Zhang J, Wang W*. Combined Shikonin-Loaded MPEG-PCL Micelles Inhibits Effective Transition of Endothelial-to-Mesenchymal Cells. International Journal of Nanomedicine. 2022,17:4497-4508.

  2. He J, Deng Y, Ren L, Jin Z, Yang J, Yao F, Zheng Z, Liu Y, Wang B, Zhang Y, Nan G, Wang W* Lin R. Isoliquiritigenin from licorice flavonoids attenuates NLRP3-mediated pyroptosis by SIRT6 in vascular endothelial cells. Journal of Ethnopharmacology. 2022, 303:115952.

  3. Chen L, Shang X, Wang B, Wang G, Jin Z, Yao F, Yue Z, Bai L, Wang R, Zhao S, Liu E, Wang W*. HDAC3 inhibitor suppresses endothelial-to-mesenchymal transition via modulating inflammatory response in atherosclerosis. Biochemical Pharmacology. 2021,192:114716.

  4. Chen L, Wang G, He J, Yang X, Zheng Z, Deng Y, Liu Y, Chen D, Lin R, Wang W*. SIRT6 inhibits endothelial-to-mesenchymal transition through attenuating the vascular endothelial inflammatory response. International Immunopharmacology. 2021,101:108240.

  5. Wang W, Chen L, Shang C, Jin Z, Yao F, Bai L, Wang R, Zhao S, Liu E. miR-145 inhibits the proliferation and migration of vascular smooth muscle cells by regulating autophagy. Journal of Cellular and Molecular Medicine, 2020,12:6658-6669.

  6. Wang W, Shang C, Zhang W, Jin Z, Yao F, He Y, Wang B, Li Y, Zhang J, Lin R. Hydroxytyrosol NO regulates oxidative stress and NO production through SIRT1 in diabetic mice and vascular endothelial cells. Phytomedicine, 2019,52:206-215.

  7. Li Y, Yao F, Shang C, Ren F, Zhang J, Li Y, Yang G, Lin R, Wang W*. Preparation, characterization and in vivo evaluation of pharmacological activity of different crystal forms of ibuprofen. Pakistan Journal of Pharmaceutical Sciences, 2019,32:2139-2147.

  8. Wang W, Chen Y, Bai L, Zhao S, Wang R, Liu B, Zhang Y, Fan L, Liu E. Transcriptomic analysis of the liver of cholesterol-fed rabbits reveals altered hepatic lipid metabolism and inflammatory response. cientific Reports, 2018,8:6437.

  9. Wang W, Jing T, Yang X, He Y, Wang B, Xiao Y, Shang C, Zhang J, Lin R. Hydroxytyrosol regulates the autophagy of vascular adventitial fibroblasts through SIRT1-mediated signaling pathway. Canadian Journal of Physiology and Pharmacology, 2018,96:88-96.

  10. Wang W, Li T, Jing T, Li Y, Yang X, He Y, Zhang W, Zhang J, Lin R. SIRT1 regulates the inflammatory response of vascular adventitial fibroblasts through autophagy and related signaling pathway. Cellular Physiology and Biochemistry, 2017,41:569-582.

  11. Wang W, Liu E, Zhang J, Li Y, Yang X, He Y, Zhang W, Jing T, Lin R. Activation of PPAR alpha by fenofibrate inhibits apoptosis in vascular adventitial fibroblasts partly through SIRT1-mediated deacetylation of FoxO1. Experimental Cell Research, 2015,338:54-63.

  12. Wang W, Zhang J, Li Y, Yang X, He Y, Li T, Ren F, Zhang J, Lin R. Divalproex sodium enhances the anti-leukemic effects of imatinib in chronic myeloid leukemia cells partly through SIRT1. Cancer Letters, 2015,356:791-799.

  13. Wang W, Bai L, Qiao H, Li Y, Yang L, Zhang J, Lin R, Ren F, Zhang J, Ji M. The protective effect of fenofibrate against TNF-α-induced CD40 expression through SIRT1-mediated deacetylation of NF-κB in endothelial cells. Inflammation, 2014, 37(1):177-185.

  14. Wang W, Lin Q, Lin R, Zhang J, Ren F, Zhang J, Ji M, Li Y. PPARα agonist fenofibrate attenuates TNF-α-induced CD40 expression in 3T3-L1 adipocytes via the SIRT1-dependent signaling pathway. Experimental Cell Research, 2013, 319(10):1523-1533.

  15. Wang W, Yan C, Zhang J, Lin R, Lin Q, Yang L, Ren F, Zhang J, Ji M, Li Y. SIRT1 inhibits TNF-α-induced apoptosis of vascular adventitial fibroblasts partly through the deacetylation of FoxO1. Apoptosis, 2013, 18(6):689-701.

  16. Wang W, Lin R, Zhang J, Mao Y, Bu X, Ji Q, Zhai X, Lin Q, Zhang K. Involvement of fatty acid metabolism in the hepatotoxicity induced by divalproex sodium. Human & Experimental Toxicology, 2012, 31(11):1092-1101.

  17. Wang W, Lin R, Zhang H, Lin Q, Yang L, Zhang K, Ren F. The effects of Buyang Huanwu Decoction on hemorheological disorders and energy metabolism in rats with coronary heart disease. Journal of Ethnopharmacology, 2011, 137(1): 214-220.

联系方式

Email: szb2013072@xjtu.edu.cn

联系电话:029-82655363

联系地址:西安市雁塔区雁塔西路76号西安交通大学医学部

个人主页:http://gr.xjtu.edu.cn/web/szb2013072

 

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