基本信息

张伊

教授

博士生导师

电子邮箱：zhangyixjtu@xjtu.edu.cn

研究方向

心血管病理生理学：

1. 鞘磷脂信号介导心脏重构和纤维化的病理机制；

2. 鞘磷脂信号对血管内皮功能的调控作用及影响；

3. 心肌肌浆网钙信号调控心律失常的作用机制。

教育及工作经历

1. 2024.01~至今，西安交通大学医学部,基础医学院,生理学与病理生理学系，教授

2. 2017.11~2023.12，西安交通大学医学部,基础医学院,生理学与病理生理学系，副教授

3. 2012.11~2017.10，美国康奈尔大学威尔医学院病理与实验药物学系，博士后

4. 2007.09~2012.07，北京大学分子医学研究所，生物物理学，博士（导师：中国科学院院士程和平教授）

5. 2003.09~2007.07，中国农业大学，学士

业绩简介

本人研究方向主要围绕细胞内鞘磷脂信号和钙信号的病理生理调控过程及其对心血管系统的影响，主要的研究成果包括：

1. 从力生物学调控的全新角度，阐述了病理性机械牵张通过调控心肌细胞肌浆网钙泄漏，导致房颤、心衰等心脏疾病的致病机制（Cardiovasc Res，2021，IF:14.239，入选ESI高被引论文）。

2. 揭示了S1P/S1PR1通过调控内质网钙信号，激活K_Ca2.3/K_Ca3.1介导的内皮依赖性超极化，促进血管舒张的新机制（Arterioscler Thromb Vasc Biol，2023，IF:10.514，心血管领域知名教授Prof. Faraci撰写专文点评）。

3. 阐明了内皮Nogo-B通过抑制鞘磷脂合成，对内皮细胞及血管功能的调控作用，及其对高血压、压力超负荷心衰等疾病进程的影响（Nat Med，2015；JCI insight，2016）。

4. 发现了内皮Nogo-B通过稳定Mfn2加强线粒体相关内质网膜结构，从而促进线粒体Ca²⁺摄取和氧化应激水平，介导冠状动脉粥样硬化发生发展的病理过程（Redox Biol，2023，IF: 11.4）。

   目前共发表研究性论文24篇，其中通讯/第一作者研究性论文13篇（6篇IF>10），主持国家自然科学基金面上项目2项、中国博士后科学基金2项（包括特别资助、面上项目一等资助）、陕西省自然科学基金2项、航天医学实验项目等多项基金。

已发表SCI论文

1. Yu Zhang, Jing-Jing Li, Rui Xu, Xin-Pei Wang, Xin-Yi Zhao, Yuan Fang, Yu-Peng Chen, Shan Ma, Xiao-Hui Di, Wei Wu, Gang She, Zheng-Da Pang, Yi-Dong Wang, Xing Zhang, Wenjun Xie, Xiu-Ling Deng, Xiao-Jun Du,Yi Zhang*. Nogo-B mediates endothelial oxidative stress and inflammation to promote coronary atherosclerosis in pressure-overloaded mouse hearts.Redox Biology.2023 Dec; 68:102944.(IF=11.4)

2. 张玉，赵芯仪，谢文俊，张伊*。线粒体相关内质网膜(MAMs)在衰老相关心血管疾病中的研究进展。生理学报（Acta Physiologica Sinica）, December 25, 2023; 75(6): 799–816.

3. Jing-Jing Li^#, Xin-Yi Zhao^#, Yan Wang^#, Rui Xu, Xiao-Hui Di, Yu Zhang, Hongyan Yang, Meng-Zhuan Han, Ru-Yue Bai, Lin Xie, Zheng-Da Pang, Xing Zhang, Jianbao Zhang, Xiao-Jun Du, Xiu-Ling Deng*,Yi Zhang* (corresponding author), Wenjun Xie*. Endothelial KCa3.1 and KCa2.3 Mediate S1P (Sphingosine-1-Phosphate)-Dependent Vasodilation and Blood Pressure Homeostasis.Arterioscler Thromb Vasc Biol. 2023 May; 43(5):726-738. (IF=10.514，Commented by Prof. Faraci inArterioscler Thromb Vasc Biol. 2023 Jun;43(6):852-854)

4. Yi Zhang^#, Xiao-Zhen Ma^#, Xin-Yi Zhao, Jing-Jing Li, Shan Ma, Zheng-Da Pang, Jing Xu, Xiao-Jun Du, Xiu-Ling Deng*, Jun-Hong Wang*. AGEs-RAGE-KCa3.1 pathway mediates palmitic acid-induced migration of PBMCs from patients with type 2 diabetes.Heliyon. 2023 Mar 24; 9(4):e14823. (IF=4.0)

5. Linda Sasset^#, Onorina Laura Manzo^#,Yi Zhang^#(co-first author), Alice Marino, Luisa Rubinelli, Maria Antonietta Riemma, Madhavi Latha S Chalasani, Dragos C Dasoveanu, Fiorentina Roviezzo, Stanislovas S Jankauskas, Gaetano Santulli, Maria Rosaria Bucci, Theresa T Lu, Annarita Di Lonrenzo*. Nogo-A reduces ceramide de novo biosunthesis to protect from geart failure.Cardiovasc Res. 2023 Mar 31; 119(2):506-519. (IF=14.239)

6. Zheng-Da Pang^#, Xia Sun^#, Ru-Yue Bai, Meng-Zhuan Han, Yong-Jian Zhang, Wei Wu, Yu Zhang, Bao-Chang Lai,Yi Zhang, Yan Wang, Xiao-Jun Du, Xiu-Ling Deng*. YAP-galectin-3 signaling mediates endothelial dysfunction in angiotensin II-induced hypertension in mice.Cell Mol Life Sci. 2023 Jan 11; 80(2):38. (IF=9.207)

7. Gang She, Jin-Chan Du, Wei Wu, Tian-Tian Pu, Yu Zhang, Ru-Yue Bai,Yi Zhang, Zheng-Da Pang, Hui-Fang Wang, Yu-Jie Ren, Junichi Sadoshima, Xiu-Ling Deng, Xiao-Jun Du*. Hippo pathway activation mediates chemotherapy-induced anti-cancer effect and cardiomyopathy through causing mitochondrial damage and dysfunction.Theranostics. 2023 Jan 1; 13(2):560-577. (IF=11.600)

8. 戚瑛，赵芯仪，姚佳辉，谢文俊，张伊*。IP3R与RyR对新生大鼠心肌细胞钙振荡调控的研究。西安交通大学学报(医学版)，2022年11月，第43卷第6期，801-806.

9. Wei Wu, Mark Ziemann, Kevin Huynh, Gang She, Zheng-Da Pang,Yi Zhang, Thy Duong, Helen Kiriazis, Tian-Tian Pu, Ru-Yue Bai, Jing-Jing Li, Yu Zhang, Ming-Xia Chen, Junichi Sadoshima, Xiu-Ling Deng, Peter J Meikle, Xiao-Jun Du*. Activation of Hippo signaling pathway mediates mitochondria dysfunction and dilated cardiomyopathy in mice.Theranostics.2021 Aug 21; 11(18):8993-9008.(IF=11.600)

10. Zheng-Da Pang, Yan Wang, Zheng Song, Gang She, Xiao-Zhen Ma, Xia Sun, Wei Wu,Bao-Chang Lai, Jiao Zhang,Yi Zhang, Xiao-Jun Du, John Y.J. Shyy*, Xiu-Ling Deng*.AMPK upregulates KCa2.3 channels and ameliorates endothelial dysfunction in diet-induced obese mice.Biochem Pharmacol.2021 Jan; 183:114337.(IF=5.858)

11. Ying Qi^#, Jing-Jing Li^#, Xiao-Hui Di^#, Yu Zhang^#, Jie-Long Chen, Zi-Xuan Wu, Zi-Yue Man, Ru-Yue Bai, Fujian Lu, Jie Tong, Xue-Liang Liu, Xiu-Ling Deng, Jianbao Zhang, Xing Zhang,Yi Zhang*(corresponding author), and Wenjun Xie*. Excess sarcoplasmic reticulum-mitochondria calcium transport induced by Sphingosine-1-phosphate contributes to cardiomyocyte hypertrophy.Biochim Biophys Acta Mol Cell Res.2021 Apr; 1868(5):118970. (IF=5.011)

12. Yi Zhang^#, Ying Qi^#, Jing-Jing Li^#, Xiao-Hang Gao, Yu Zhang, Xia Sun, Wen-Jin He, Jie Tong, Jianbao Zhang, Xiu-Ling Deng, Xiao-Jun Du, Wenjun Xie*. Stretch-induced sarcoplasmic reticulum calcium leak is causatively associated with atrial fibrillation in pressure-overloaded hearts.Cardiovasc Res.2021 Mar 21;117(4):1091-1102. (IF=14.239)

13. Yi Zhang^#, Meng-Chen Hou^#, Jing-Jing Li, Ying Qi, Yu Zhang, Gang She, Yu-Jie Ren, Wei Wu, Zheng-Da Pang, Wenjun Xie, Xiu-Ling Deng*, Xiao-Jun Du*. Cardiac β-adrenoceptor activation mediates diverse and cell type-dependent changes in the expression and distribution of connexin 43.J Cell Mol Med.2020 Aug; 24(15):8505-8517. (IF=5.310)

14. Gang She, Meng-Chen Hou, Yu Zhang,Yi Zhang, Yan Wang, Hui-Fang Wang, Bao-Chang Lai, Wei-Bo Zhao, Xiao-Jun Du, Xiu-Ling Deng*. Gal-3 (Galectin-3) and KCa3.1 Mediate Heterogeneous Cell Coupling and Myocardial Fibrogenesis Driven by βAR (β-Adrenoceptor) Activation.Hypertension.2020 Feb; 75(2):393-404. (IF=7.017)

15. Alice Marino,Yi Zhang, Luisa Rubinelli, Maria Antonietta Riemma, James E. Ip, Annarita Di Lorenzo*.Pressure overload leads to coronary plaque formation, progression and myocardial events in ApoE-/- mice.JCI Insight.2019 May 2; 4(9):e128220. (IF=6.014)

16. Gregory Farber, Matthew M. Parks, Nicole Lustgarten Guahmich,Yi Zhang, Sébastien Monette, Scott C. Blanchard, Annarita Di Lorenzo, Carl P. Blobe*,ADAM10 controls the differentiation of the coronary arterial endothelium.Angiogenesis. 2019 May; 22(2):237-250. (IF=5.759)

17. Ren Xu, Alisha Yallowitz, An Qin, Zhuhao Wu, Dong Yeon Shin, Jung-Min Kim, Shawon Debnath, Gang Ji, Mathias P. Bostrom, Xu Yang, Chao Zhang, Han Dong, Pouneh Kermani, Sarfaraz Lalani, Na Li, Yifang Liu, Michael G. Poulos, Amanda Wach,Yi Zhang, Kazuki Inoue, Annarita Di Lorenzo, Baohong Zhao, Jason M. Butler, Jae-Hyuck Shim, Laurie H. Glimcher*, Matthew B. Greenblatt*, Targeting skeletal endothelium to ameliorate bone loss.Nat Med. 2018 Jun; 24(6):823-833.(IF=30.641)

18. Steven L Swendeman, Yuquan Xiong, Anna Cantalupo, Hui Yuan, Nathalie Burg, Yu Hisano, Andreane Cartier, Catherine H Liu, Eric Engelbrecht, Victoria Blaho,Yi Zhang, Keisuke Yanagida, Sylvain Galvani, Hideru Obinata, Jane E Salmon, Teresa Sanchez, Annarita Di Lorenzo, Timothy Hla*, An engineered S1P chaperone attenuates hypertension and ischemic injury.Sci Signal.2017 Aug 15; 10(492):eaal2722. (IF=6.481)

19. Anna Cantalupo, Antonella Gargiulo, Elona Dautaj, Catherine Liu,Yi Zhang, Timothy Hla, and Annarita Di Lorenzo*, S1PR1 (Sphingosine-1-Phosphate Receptor 1) Signaling Regulates Blood Flow and Pressure.Hypertension. 2017 Jun 12; 70(2): 426~434. (IF=7.017)

20. LindaSasset^#,YiZhang^#(co-first author),TeresaM. Dunn, and AnnaritaDi Lorenzo*. Sphingolipid De NovoBiosynthesis:A Rheostat ofCardiovascular Homeostasis.TrendsEndocrinolMetab.2016 Nov; 27(11):807-819. (IF=10.983)

21. YiZhang,YanHuang, AnnaCantalupo,PaulaS. Azevedo, Mauro Siragusa,Jacek Bielawski, Frank J. Giordano,and AnnaritaDi Lorenzo*. Endothelial Nogo-B regulates sphingolipid biosynthesis to promote pathological cardiac hypertrophy during chronic pressure overload.JCIInsight.2016 Apr 21; 1(5): e85484. (IF=6.014)

22. AnnaCantalupo^#,YiZhang^#(co-first author), Milankumar Kothiya, SylvainGalvani, HideruObinata,MariarosariaBucci, Frank J. Giordano,Xian-Cheng Jiang,Timothy Hla, and AnnaritaDi Lorenzo*.Nogo-B regulates endothelial sphingolipidhomeostasisto control vascular function andbloodpressure.NatMed.2015Sep; 21(9):1028-37. (IF=30.641)

23. XianhuaWang*^#,Wenjun Xie^#,YiZhang^#(co-firstauthor), Peihui Lin,Liang Han, Peidong Han,YanruWang,Zheng Chen, GuangjuJi,Ming Zheng,NoahWeisleder,Rui-Ping Xiao, HiroshiTakeshima,Jianjie Ma*, andHeping Cheng. Cardioprotectionofischemia-reperfusioninjury bycholesterol-dependentMG53-mediated membranerepair.CircRes.2010Jul 9; 107(1):76-83. (IF=15.862)

24. Chun-MeiCao,YanZhang, NoahWeisleder,Christopher Ferrante,XianhuaWang, FengxiangLv,YiZhang,Ruisheng Song,Moonsun Hwang, Li Jin, JiaojiaoGuo, Wei Peng, Geng Li,MiyukiNishi,HiroshiTakeshima,Jianjie Ma, and Rui-PingXiao*. MG53constitutes a primary determinantofcardiac ischemicpreconditioning.Circulation.2010 Jun15;121(23):2565-74.(IF=23.054)