研究领域(方向)
毒品依赖分子机制;法医学;肿瘤学
个人及工作简历
教授,医学博士,硕博士研究生导师
1988.7-1995.6原西安医科大学医学院法医系 助教
1995.7-2002.6 西安交通大学医学院法医系 讲师
2002.7-2010.1 西安交通大学医学院法医系 副教授
2010.1-至今 西安交通大学医学院法医系 教授
科研项目
1.国家自然科学基金面上项目,81972473,CXCL1及其受体介导的髓源性抑制细胞对乳腺癌细胞“干性”获得的分子机制研究,2020/01-2023/12,55万,主持。
2.国家自然科学基金面上项目,81171263,左旋CLAU对吗啡成瘾孕鼠子代海马突触可塑性损伤的保护作用,2012/01-2015/12,54万,已结题,主持
3.国家自然科学基金面上项目,30873049,吗啡记忆-唤醒过程中海马区BDNF对NMDAR的调控作用,2009/01-2011/12,25万,已结题,主持
4.陕西省科技攻关项目,2011K12-57,BDNF与NMDAR在吗啡记忆-唤醒过程中的作用与临床价值研究,2011/01-2012/12,7万,已结题,主持
5.陕西省科技攻关项目,2007k10-01,多巴胺受体在吗啡诱导的Fos家族基因表达中的调制作用及新型戒毒药物的开发研究,2007/01-2008/12,2万,已结题,主持
6.陕西省自然科学基金,2003C211,吗啡依赖中阿片受体对乙酰胆碱受体的调制作用,2003/01-2004/12,2万,已结题,主持
7.国家自然科学基金青年项目,81701869,利用牙齿/骨骼MRI及深度学习网络构建西北汉族青少年年龄评价体系的研究,2018/01-2022/12,20万,在研,第二位
学术及科研成果、专利、论文
(1)Maoying Zhang,Jianhui Gao,Fang Shi,Jingyuan Ma,Chongya Huang, Shanzhi Gu*. Forensic Identification of Traumatic Thoracic Aortic Pseudoaneurysm.
Journal of Forensic Science and Medcine,2020,6(1):37-39.
(2)张毛影,高建辉,史芳,马静媛,顾珊智*.隐匿性间接视神经损伤法医学鉴定,中国法医学杂志,2020,35(2):251-252.
(3)Xu Li,Wenjing Zou,Yuzhen Wang,Zijun Liao,Lina Li,Yang Zhai,Lingxiao Zhang,Shanzhi Gu,Xinhan Zhao.Plasma-based microRNA signatures in early diagnosis of breast cancer.Molecular Genetics & Genomic Medicine,2019,1-10
(4)Gaili An,Fang Wu,Shangke Huang,Lu Feng,Jun Bai,Shanzhi Gu* and Xinhan Zhao. Effects of CCL5 on the biological behavior of breast cancer and the mechanisms of its interaction with tumor-associated macrophages.ONCOLOGY REPORTS.2019,42:2499-2511
(5)史芳,张毛影,马静媛,黄崇亚,高建辉,顾珊智*.涉及骨科医疗损害案件的法医学鉴定. 法医学杂志,2019,35(1):52-56
(6)史芳,张毛影,马静媛,黄崇亚,高建辉,顾珊智*.骨科医疗损害司法鉴定案例分析研究. 中国卫生质量管理. 2018,25(4):85-87
(7)Shangke Huang,Lu Feng,Gaili An,Xiaojin Zhang,Zixuan Zhao,Rui Han,Fuxi Lei,Yujiao Zhang,Anqi Luo,Xin Jing,Lin Zhao,Shanzhi Gu*,Xinhan Zhao,Lingxiao Zhang.Ribosome display and selection of single-chain variable fragments effectively inhibit growth and progression of microspheres in vitro and in vivo.Caner science,2018,109:(5):1503-1512
(8)Jingyuan Ma, Fang Shi,Chongya Huang and Shanzhi Gu*.Forensic Identification of Bipartite Patella Misdiagnosed as Patella Fracture. J Forensic Sci.2017,62(4):1089-1091
(9)Huang CY, Xun XJ, Wang AJ, Gao Y, Ma JY, Chen YT, Jin TB, Hou P, Gu SZ*. CHRNA5 polymorphisms and risk of lung cancer in Chinese Han smokers. Am J Cancer Res. 2015 Sep 15; 5(10): 3241-8.
(10)Shan Shao , Xiaoai Zhao, Xiaojin Zhang, Minna Luo , Xiaoxiao Zuo , Shangke Huang , Ying Wang , Shanzhi Gu* and Xinhan Zhao*.Notch1 signaling regulates the epithelial–mesenchymal transition and invasion of breast cancer in a Slug-dependent manner. Molecular Cancer.2015,14(28):1-17
(11)Yuan Ma J, Zhi Gu S*, Meng M, Hui Dang Y, Ya Huang C, Onaivi ES. Regional expression of extracellular signal-regulated kinase 1 and 2 mRNA in a morphine-induced conditioned place preference model. Brain Res. 2014 Jan 16;1543:191-9.
(12)Min Meng , Xinhan Zhao , Yonghui Dang, Jingyuan Ma, Lixu Li, Shanzhi Gu*. Region-specific expression of brain-derived neurotrophic factor splice variants in morphine conditioned place preference in mice. Brain Res. 2013 Jun 26;1519:53-62.
(13)Tian-Jie Qin, Gai-Li An, Xin-Han Zhao, Fang Tian, Xiao-Hua Li, Juan-Wen Lian, Bo-Rong Pan, Shan-Zhi Gu*. Combined treatment of oxaliplatin and capecitabine in patients with metastatic esophageal squamous cell cancer. World J Gastroenterol 2009 February 21; 15(7): 871-876
(14)Gu SZ, Zhao XH*, Zhang LX, Li L, Wang ZY, Meng M, An GL. Anti-angiogenesis effect of generation 4 polyamidoamine/ vascular endothelial growth factor antisense oligodeoxynucleotide on breast cancer in vitro, J Zhejiang Univ Sci B. 2009 Mar;10(3):159-67.
(15)马静媛,荆小莉,马军,顾珊智*. 非法行医致伤法医学鉴定,法医学杂志,2014,30(5):401-401.
(16)马静媛,顾珊智*,马德刚,张转利,儿童下肢长骨骨折后过度生长的成因分析,法医学杂志,2012,28(3):227-228.
(17)顾珊智*,王华丽,付鹏忍,高雅. 外伤性迟发性颈内动脉-海绵窦瘘1例. 法医学杂志,2009,25(2):155-156.
(18)顾珊智*,付鹏忍,王华丽,韩卫. 手枪电钻刺伤颈部致声带麻痹1例. 法医学杂志,2009,25(2):156-157.
联系方式
联系电话:13991993927
电子邮箱:gushanzhi@mail.xitu.edu.cn