研究领域（方向）
（1）肠道菌群及代谢影响心血管疾病的机制，（2）心血管药物和菌群互作机制
个人及工作简历
李铤，西安交通大学第一附属医院, 副研究员、主治医师。主要从事心血管疾病介入诊疗等临床工作，及肠道微生物调控代谢性心血管病机制研究。主持国家自然科学基金2项，科技部重点研发计划1项。以第一作者或通讯作者在Cell Host Microbe、Gut等杂志发表论文10余篇，最高影响因子31.7分。获中华科技奖、陕西省科技新星、陕西省优秀博士论文等。
教育经历：
[1]2015-01至 2016-06, 麻省理工学院, 生物学, 博士（联合培养）
[2]2013-09至 2016-06, 第四军医大学, 内科学, 博士
[3]2010-09至 2013-06, 第四军医大学, 内科学, 硕士
[4]2005-09至 2010-06, 第四军医大学, 临床医学, 学士
科研和工作经历：
[1]2022-12至 今, 西安交通大学, 第一附属医院, 副研究员，主治医师。
[2]2018-06至 2022-12, 西安交通大学, 第一附属医院, 助理研究员，住院医师
[3]2015-01至 2016-06, 麻省理工学院, 科赫研究所, 无
科研项目
近5年主持项目。
[1]国家自然科学基金委员会, 面上项目, 82370458, 肠道联乳酸杆菌通过β鼠胆酸-FXR通路抑制动脉粥样硬化的机制研究, 2024-01-01 至 2027-12-31, 49万元, 在研, 主持
[2]国家自然科学基金委员会, 青年科学基金项目, 82000474, 肠道菌-胆汁酸轴通过FXR通路发挥抑制动脉粥样硬化与促进消化道损伤的双重作用, 2021-01-01 至 2023-12-31, 24万元, 结题, 主持
[3]国家科技部, 国家重点研发计划青年项目, 2021YFA0805400, RNA m6A 修饰对肠道发育编程的调节,2021-12 至 2026-12, 300万元, 在研, 主持
[4]陕西省科技厅, 陕西省青年科技新星项目, 2021KJXX-04, 胆汁酸UDCA轴通过FXR通路发挥抑制动脉粥样硬化的研究, 2021-01 至 2022-12, 10万元, 结题, 主持
[5]西安交通大学, 自由探索与创新项目, XZY012019093, 胆汁酸通过miR-17-92调控动脉粥样硬化的机制研究, 2019-01 至 2021-12, 15万元, 结题, 主持
学术及科研成果、专利、论文
在国内外学术刊物发表论文情况。
[1]Ting Li; Ning Ding; Hanqing Guo; Rui Hua; Zehao Lin; Huohuan Tian; Yue Yu; Daiming Fan; Zuyi Yuan; Frank J. Gonzalez; Yue Wu ; A gut microbiota-bile acid axis promotes intestinal homeostasis upon aspirin-mediated damage.,Cell Host & Microbe, 2024, 32(2): 191-208
[2]Hanqing Guo; Kun Zhuang; Ning Ding; Rui Hua; Hailing Tang; Yue Wu; Zuyi Yuan;Ting Li; Shuixiang He; High-fat diet induced cyclophilin B enhances STAT3/lncRNA-PVT1 feedforward loopand promotes growth and metastasis in colorectal cancer,Cell Death & Disease,2022, 13(10): 1-17
[3]Rui Hua, Ning Ding, Hanqing Guo, Yue Wu, Zuyi Yuan,Ting Li. Contrast-Induced Acute Kidney Injury in Patients on SGLT2 Inhibitors Undergoing Percutaneous Coronary Interventions: A Propensity-Matched Analysis.Frontiers in Cardiovascular Medicine, 2022, 9
[4]Ting Li; Hanqing Guo; Hong Li; Yanzhi Jiang; Kun Zhuang; Chao Lei; Jian Wu; Haining Zhou; Ruixue Zhu; Xiaodi Zhao; Yuanyuan Lu; Chongkai Shi; Yongzhan Nie; Kaichun Wu; Zuyi Yuan; Daiming Fan; Yongquan Shi ; MicroRNA-92a-1-5p increases CDX2 by Targeting FOXD1 in Bile-acids-induced Gastric Intestinal Metaplasia,Gut, 2019, 68(10): 1751-1763
[5]Ting Li; Hanqing Guo; Xiaodi Zhao; Jiang Jin; Lifeng Zhang; Hong Li; Yuanyuan Lu; Yongzhan Nie; Kaichun Wu; Yongquan Shi; Daiming Fan ; Gastric Cancer Cell Proliferation and Survival Is Enabled by a Cyclophilin B/STAT3/miR-520d-5p Signaling Feedback Loop,Cancer Research, 2017, 77(5): 1227-1240
[6]Feng Du; Tianyu Cao; Huahong Xie;Ting Li; Lina Sun; Hao Liu; Hao Guo; Xin Wang; Qi Liu; Taewan Kim; Jeffrey L Franklin; Ramona Graves-Deal; Weili Han; Zuhong Tian; Minghui Ge; Yongzhan Nie; Daiming Fan; Robert J Coffey; Yuanyuan Lu; Xiaodi Zhao ; KRAS Mutation-Responsive miR-139-5p inhibits Colorectal Cancer Progression and is repressed by Wnt Signaling,Theranostics, 2020,10(16): 7335-7350
[7]Ting Li; Hanqing Guo; Ying Song; Xiaodi Zhao; Yongquan Shi; Yuanyuan Lu; Sijun Hu; Yongzhan Nie; Daiming Fan; Kaichun Wu ; Loss of vinculin and membrane-bound eta-catenin promotes metastasis and predicts poor prognosis in colorectal cancer,Molecular Cancer, 2014, 13:263
[8]Ting Li; Lu Yuanyuan; Zhao Xiaodi; Guo Hanqing; Liu Changhao; Li Hong; Shi Yongquan; Fan Daiming ; MicroRNA-296-5p increases proliferation in gastric cancer through repression of Caudalrelated homeobox 1,Oncogene., 2014, 33(1): 783-93
[9]Xiaodi Zhao; Lijie He;Ting Li;Yuanyuan Lu; Shuli Liang; Hao Guo; Ming Bai; Huahong Xie; Lin Zhou; Gaofei Shen; Changcun Guo; Feihu Bai; Kaichun Wu; Yongzhan Nie; Daiming Fan ; SRF expedites metastasis and modulates the epithelial to mesenchymal transition by regulating miR-199a-5p expression in human gastric cancer,Cell Death Differentiation,2014, 21(12): 1900-1913
[10]Haihua Xiao; Ruogu Qi;Ting Li; Samuel G Awuah; Yaorong Zheng; Wei Wei; Xiang Kang; Haiqin Song; Wang Y; Molly A Bird; Xiabin Jing; Micheal B. Yaffe; Michael J. Birrer; Paiman Peter Ghoroghchian ; Maximizing Synergistic Activity When Combining RNAi and Platinum-Based Anticancer Agents,The Journal of American Chemical Society,2017, 139(8): 3033-3044
[11]Ruogu Qi; Yongheng Wang; Peter M.Bruno; Haihua Xiao; Yingjie Yu;Ting Li;Sam Lauffer; Wei Wei; Qixian Chen; Xiang Kang; Haiqin Song; Xi Yang; Xing Huang; Alexandre Detappe; Ursula Matulonis; David Pepin; Michael T. Hemann; Michael J Birrer; Peter Ghoroghchian; Nanoparticle conjugates of a highly potent toxin enhance safety and circumvent platinum resistance in ovarian cancer,Nature Communications,2017, 8(1)
[12]ShengPeng Wang; Bianbian Wang; Yue Shi; Tanja Möller; Rebekka I. Stegmeyer; Boris Strilic;Ting Li; Zuyi Yuan; Changhe Wang; Nina Wettschureck; Dietmar Vestweber; Stefan Offermanns ; Mechanosensation by endothelial PIEZO1 is required for leukocyte diapedesis,Blood, 2022, 140(3): 171-183
[13]Ting Li;Ning Ding; Hanqing Guo; Rui Hua; Zuyi Yuan; Yue Wu ; Aspirin Impairs Intestinal Homeostasis Through Gut Microbiota-Bile-Acids Axis.,Gut, 2022, 71(Suppl 2): 1-3 (摘要)
[14]Ting Li; Hanqing Guo; Zuyi Yuan; Yongquan Shi; Daiming Fan ; Bile Reflux Promotes Gastric Intestinal Metaplasia Through A MicroRNA92a/Sirt2/RelA/CDX2 Axis,Gastroenterology, 2020, 158(6): 1016-1017 (摘要)
科研奖励
[1]陕西省科技新星, 陕西省科技厅, 省部级奖励, 省部一等奖, 2021(李铤) (科研奖励)
[2]2018年陕西省优秀博士学位论文, 陕西省教育厅, 其他, 省部一等奖, 2018(李铤) (科研奖励)
[3]西部人群冠心病危险因素、病理机制及临床诊治, 中华医学会, 科技进步, 2020(袁祖贻; 吴岳; 陈涛; 刘军辉; 田雨灵; 周娟; 王丽君; 李铤) (科研奖励)
联系方式
电子邮箱：li.ting@xjtu.edu.cn
联系电话：13571805586
个人主页：无
联系地址：陕西省西安市雁塔区雁塔西路277号西安交通大学第一附属医院心内科
