研究领域（方向）
（1）自身免疫性疾病的发病机制与新治疗；（2）线粒体、溶酶体、自噬体等亚细胞结构在致病性免疫细胞中的作用
个人及工作简历
王静，女，2015年毕业于西安交通大学，后就职于西安交通大学第一附属医院风湿免疫科。任中国医师协会风湿免疫科医师分会青年委员，陕西省医学会风湿免疫分会青年委员会委员。主持国家自然科学基金2项，陕西省自然科学基础研究计划1项，以第一作者或通讯作者在Clinical immunology（10.2分）等杂志发表SCI论文10篇；参与获得陕西科技进步二等奖。
科研项目
1. 国家自然科学基金面上项目，82371811，Rab32调控自噬溶酶体形成参与SLE致病性B细胞分化的机制，2024/01-2027/12, 46万元，在研、主持。
2. 国家自然科学基金青年项目，81702119，Atg13介导线粒体自噬新途径调控RA滑膜成纤维细胞凋亡的机制，2018/01-2020/12, 20万元，结题、主持。
3. 陕西省自然科学基础研究计划，2018JQ8031，Atg13介导线粒体自噬调控RA滑膜成纤维细胞凋亡的机制；到款数额：3万元；完成时间2019-12-31；结题、主持。
学术及科研成果、专利、论文
[1] Jing Wang; Bomiao Ju; Li Zhu; Hanchao Li; Jing Luo; Jing Zhang; Nan Hu; Lingfei Mo;Yanhua Wang; Ying Pan; Jing Huang; Xiaohong Lv; Dan Pu; Zhiming Hao; Lan He; Yuanyuan Li ; The rapid inhibition of B cell activation markers by belimumab was associated with disease control in the patients of systemic lupus erythematosus, Frontiers in Pharmacology, 2023, 14(1080730). 影响因子=5.988
[2] Zheng, J., L. Zhu, B. Ju, J. Zhang, J. Luo, Y. Wang, X. Lv, D. Pu, L. He, and J. Wang. 2022. 'Peripheral immunophenotypes associated with the flare in the systemic lupus erythematosus patients with low disease activity state', Clin Immunol, 245: 109166.影响因子=10.190
[3] Jia, Y., J. Zhang, L. Mo, B. Ju, N. Hu, Y. Wang, P. Wang, J. Zheng, L. He, and J. Wang. 2022. 'Low positivity rates for HBeAg and HBV DNA in rheumatoid arthritis patients: a case-control study', BMC Infect Dis, 22: 570.
[4] Wang, Z., R. Qian, Y. Wang, L. Mo, B. Ju, N. Hu, P. Wang, L. He, and J. Wang. 2022. 'QTc interval prolongation in the patients with primary biliary cholangitis', Ann Noninvasive Electrocardiol, 27: e12925.
[5] Wang, J., Y. He, D. Jin, J. Liu, J. Zheng, N. Yuan, Y. Bai, T. Yan, Y. Yang, Y. Liu, S. Zhang, Y. Zhao, and T. Chen. 2017. 'No response to hepatitis B vaccine in infants born to HBsAg(+) mothers is associated to the transplacental transfer of HBsAg', Infect Dis (Lond), 49: 576-83.
[6] Wang, J., C. Hu, Y. Chen, Z. Liu, Q. Yu, S. Yang, J. Dong, Y. Yang, Y. Wu, D. Ren, N. Yao, D. Guo, Z. Tian, Y. Zhao, T. Chen, Y. He, and J. Liu. 2019. 'HBV reactivation during direct-acting antiviral therapy in hepatitis B and C coinfected patients undergoing haemodialysis', Antivir Ther, 24: 77-84.
[7] Wang, J., B. Ju, L. Zhu, H. Li, J. Luo, J. Zhang, N. Hu, L. Mo, Y. Wang, Y. Pan, J. Huang, X. Lv, D. Pu, Z. Hao, L. He, and Y. Li. 2023. 'The rapid inhibition of B-cell activation markers by belimumab was associated with disease control in systemic lupus erythematosus patients', Front Pharmacol, 14: 1080730.
[8] Wang, J., J. Liu, Q. Yu, L. Jin, N. Yao, Y. Yang, T. Yan, C. Hu, Y. He, Y. Zhao, T. Chen, and J. Zheng. 2021. 'High Prevalence of Preexisting HBV Polymerase Mutations in Pregnant Women Does Not Limit the Antiviral Therapy Efficacy', Can J Infect Dis Med Microbiol, 2021: 6653546.
[9] Xu, K., X. Ren, B. Ju, Y. Aihaiti, Y. Cai, Y. Zhang, L. He, and J. Wang. 2020. 'Clinical markers combined with HMGB1 polymorphisms to predict efficacy of conventional DMARDs in rheumatoid arthritis patients', Clin Immunol, 221: 108592.
[10] Chen, T., J. Liu, Q. Yu, N. Yao, Y. Yang, Y. Wu, D. Ren, Z. Tian, Y. Zhao, and J. Wang. 2019. 'Tenofovir plus hepatitis B immunoglobulin treatment resulted in a rapid HBV DNA load decline in high-risk pregnant women who missed the optimal time window of antiviral prophylaxis', Antivir Ther, 24: 125-31.
[11] Ju, B., J. Wang, L. Mo, J. Huang, Z. Hao, X. Lv, D. Pu, and L. He. 2022. 'Elevated CD19(+)Siglec-10(+) B cell levels are correlated with systemic lupus erythematosus disease activity', Int Immunopharmacol, 102: 108403.
[12] Liu, J., J. Wang, C. Qi, F. Cao, Z. Tian, D. Guo, T. Yan, Q. Li, S. Yang, J. Fu, X. Tang, X. Kou, N. Liu, Z. Jiang, Y. Zhao, and T. Chen. 2018. 'Baseline Hepatitis B Virus Titer Predicts Initial Postpartum Hepatic Flare: A Multicenter Prospective Study', J Clin Gastroenterol, 52: 902-07.
[13] Liu, J., J. Wang, T. Yan, D. Du, C. Qi, F. Cao, N. Yao, Y. Yang, Y. He, Z. Tian, D. Ren, L. Zhu, T. Chen, and Y. Zhao. 2019. 'Efficacy and safety of telbivudine and tenofovir disoproxil fumarate in preventing hepatitis B vertical transmission: A real-life practice', J Viral Hepat, 26: 1170-77.
[14] Mo, L., J. Wang, B. Ju, Y. Wang, J. Luo, J. Tian, and L. He. 2021. 'Assessment of Low Bone Mineral Density in Untreated Patients with Takayasu's Arteritis', Biomed Res Int, 2021: 6489631.
[15] Pan, Y., J. Wang, L. He, and F. Zhang. 2021. 'MicroRNA-34a Promotes EMT and Liver Fibrosis in Primary Biliary Cholangitis by Regulating TGF-beta1/smad Pathway', J Immunol Res, 2021: 6890423.
[16] Chen, T., J. Wang, H. Qiu, Q. Yu, T. Yan, C. Qi, F. Cao, Z. Tian, D. Guo, N. Yao, Y. Yang, Y. He, Y. Zhao, and J. Liu. 2018. 'Different interventional criteria for chronic hepatitis B pregnant women with HBeAg(+) or HBeAg(-): Epidemiological data from Shaanxi, China', Medicine (Baltimore), 97: e11406.
[17] He, Y., L. Jin, J. Wang, Z. Yan, T. Chen, and Y. Zhao. 2015. 'Mechanisms of fibrosis in acute liver failure', Liver Int, 35: 1877-85.
[18] Hu, N., J. Zhang, J. Wang, P. Wang, J. Wang, Y. Qiang, Z. Li, T. Wu, X. Wang, Y. Wang, J. Li, X. Liu, J. Zhang, X. Feng, B. Ju, Z. Hao, D. Pu, X. Lu, Q. Wang, and L. He. 2022. 'Biomarkers of joint metabolism and bone mineral density are associated with early knee osteoarthritis in premenopausal females', Clin Rheumatol, 41: 819-29.
[19] Hu, N., L. Zhu, L. Zhang, J. Wang, Y. Wang, J. Luo, L. He, Z. Hao, and L. Zhang. 2022. 'Immunomodulatory effect and safety of TNF-alpha RNAi mediated by oral yeast microcapsules in rheumatoid arthritis therapy', Mater Today Bio, 16: 100384.
[20] Jin, L., H. Gao, J. Wang, S. Yang, J. Wang, J. Liu, Y. Yang, T. Yan, T. Chen, Y. Zhao, and Y. He. 2017. 'Role and regulation of autophagy and apoptosis by nitric oxide in hepatic stellate cells during acute liver failure', Liver Int, 37: 1651-59.
[21] Ju, B., L. Zhu, J. Wang, J. Zheng, Z. Hao, J. Luo, J. Zhang, N. Hu, Q. An, X. Feng, Y. Huo, and L. He. 2022. 'The proportion and phenotypic changes of CD4(+)CD25(-)Foxp3(+) T cells in patients with untreated rheumatoid arthritis', BMC Immunol, 23: 41.
[22] Li, J., C. H. Hu, Y. Chen, M. M. Zhou, Z. J. Gao, M. J. Fu, J. Wang, J. Z. Li, T. Y. Chen, Y. R. Zhao, and Y. L. He. 2021. 'Characteristics of Peripheral Lymphocyte Subsets in Patients With Acute-On-Chronic Liver Failure Associated With Hepatitis B', Front Med (Lausanne), 8: 689865.
[23] Liu, J., Y. Feng, J. Wang, X. Li, C. Lei, D. Jin, W. Feng, Y. Yang, Y. He, Y. Li, D. Du, X. Zhang, L. Jin, T. Yan, T. Chen, and Y. Zhao. 2015. 'An "immune barrier" is formed in the placenta by hepatitis B immunoglobulin to protect the fetus from hepatitis B virus infection from the mother', Hum Vaccin Immunother, 11: 2068-76.
[24] Wang, Y., L. Zhu, B. Ju, J. Luo, Q. Li, X. Lv, D. Pu, Z. Hao, J. Wang, and L. He. 2022. 'Alterations of peripheral blood B cell subsets in Chinese patients with adult idiopathic inflammatory myopathies', Clin Exp Rheumatol, 40: 260-66.
[25] Yang, Y., L. Jin, Y. L. He, K. Wang, X. H. Ma, J. Wang, Z. Yan, Y. L. Feng, Y. Q. Li, T. Y. Chen, H. L. Liu, and Y. R. Zhao. 2013. 'Hepatitis B virus infection in clustering of infection in families with unfavorable prognoses in northwest China', J Med Virol, 85: 1893-9.
[26] Zhang, X., L. Jin, Z. Tian, J. Wang, Y. Yang, J. Liu, Y. Chen, C. Hu, T. Chen, Y. Zhao, and Y. He. 2019. 'Nitric oxide inhibits autophagy and promotes apoptosis in hepatocellular carcinoma', Cancer Sci, 110: 1054-63.
联系方式
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联系电话：18092691661
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联系地址： 陕西省西安市雁塔区雁塔西路277号
