王悦

研究领域(方向)

内分泌与代谢性疾病临床与基础研究

个人及工作简历

王悦,MD, PhD,控制科学与工程博士后,副研究员、主治医师、博士研究生导师,西安交通大学第一附属医院保健办公室主任。

三秦英才特支计划青年拔尖人才,陕西省青年科技新星,中华医学会内分泌代谢分会甲状腺学组委员,陕西省医师协会内分泌代谢科医师分会委员,陕西省抗癌协会肿瘤预防与健康管理专业委员会常务委员,陕西省老年保健学会委员。

获2021年陕西省科学技术进步奖一等奖 (排名第三)以及2024年陕西省科学技术进步奖二等奖(排名第一)。先后主持国家自然科学基金2项,陕西省重点研发计划,西安交大青年创新团队等,累积主持科研经费400余万。作为研究骨干参与科技部重点研发计划2项。近三年以第一作者或通讯作者共发表SCI论文12篇,累积影响因子 100余分。4项发明专利获批,4项软件著作权获批。

科研项目

CD4+细胞毒性T细胞通过mTOR通路促进Graves眼病发生的机制及干预研究

国家自然科学基金面上项目

主持

TSHR-CAR/Foxp3 mRNA诱导的Treg细胞靶向治疗小鼠Graves病的机制研究

国家自然科学基金青年项目

主持

基于机器学习算法的T细胞受体模型预测Graves甲亢患者眼病的发生

陕西省青年科技新星

主持

基于机器学习算法的T细胞受体模型预测Graves甲亢患者眼病的发生

中央高校基本科研业务费

主持

应用T细胞受体模型预测Graves甲亢患者眼病的发生

中国博士后基金面上项目

主持

TSHR-Foxp3 mRNA靶向治疗小鼠Graves病

陕西省自然科学基金

主持

甲巯咪唑联合雷帕霉素对难治性Graves甲亢患者临床治疗效果的研究

西安交通大学第一附属医院临床研究基金面上项目

主持

TSHR-CAR/Foxp3 mRNA诱导的Treg细胞靶向治疗小鼠Graves病

西安交通大学医学“基础-临床”融合创新项目

主持

基于医工交叉的甲亢诊疗新技术体系研究与开发

陕西省重点研发项目

——关键核心技术攻关-社会发展领域

主持

三秦英才特殊支持计划青年拔尖人才


三秦英才特殊支持计划青年拔尖人才

主持

西罗莫司联合甲强龙与麦考酚酸酯联合甲强龙在难治性甲状腺相关眼病的疗效及安全性比较研究

一附院临床研究项目

主持

免疫与临床医学研究团队

2024年交大青年创新团队


主持


学术及科研成果、专利、论文

一、科研获奖

1. 2020年 陕西省科学技术进步奖 一等奖 施秉银,伍丽萍,王悦,吴晓燕,强薇,刘晓梅,刘淑,赵艳茹,叶凯,刘冰,张萌,“甲状腺疾病关键防治技术的研究与推广应用”

2. 2024年,陕西省科学技术进步奖 二等奖 王悦 张萌 施秉银 郭辉 陈子怡 孙玉石 庄金隆 王玲 周星辰 齐昕,Graves眼病免疫防治的体系建立及推广应用

2. 2014年 西安市优秀自然科学论文奖 一等奖 施秉银,王悦,伍丽萍,“实验性猕猴Graves病模型的制备及机制研究”

3. Yue Wang, Bingyin Shi.Rapamycin effectively ameliorates collagen and lipid deposition of the Graves’ ophthalmopathy in Balb/c mice Abstract Travel Grant Awarded of European Group On Graves’Orbitopathy 2019

二、人才称号

三秦英才特殊支持计划青拔人才、陕西省青年科技新星、交大青年创新团队

三、学术兼职

1. 中华医学会内分泌代谢分会甲状腺学组 委员 2019 中华医学会

2. 陕西省医师协会内分泌代谢科医师分会 委员 2018 陕西省医师协会

3. 中国研究型医院学会互联网医院分会 青年委员 2020 中国研究型医院学会

4. 中国研究型医院学会互联网医院分会内分泌代谢疾病学组 秘书 2020 中国研究型医院学会

5. 美国内分泌学会 委员 2018 美国内分泌学会

6. 陕西省健康促进与教育协会妊娠内分泌代谢病分会 委员 2021  陕西省健康促进与教育协会

7. 陕西省抗癌协会肿瘤预防与健康管理专业委员会 常务委员 2023 陕西省抗癌协会


四、代表性论文

著作或论文名称;出版单位或发表刊物名称;期号、起止页码;

作者排序

(按顺序写出全部作者,通讯作者标注*号)

出版或发表年度

期刊影响因子

他引次数

SCI

A novel CD4+CTL subtype   characterized by chemotaxis and inflammation is involved in the pathogenesis   of Graves' orbitopathy.   Cellular & Molecular Immunology. 2021   Mar;18(3):735-745

Yue Wang, Ziyi Chen, Tingjie Wang, Hui Guo, Yufeng Liu, Ningxin Dang, Shiqian   Hu, Liping Wu, Chengsheng Zhang, Kai Ye*, Bingyin Shi*

2021

24.1

53

Selenium   deficiency is linearly associated with hypoglycemia in healthy adults. Redox   Biology. 2020 Oct;37:101709

Yue Wang , Rijntjes Eddy, Qian   Wu, Hongjun Lv; Chuqi Gao; Bingyin Shi *, Lutz Schomburg*

2020

13.1

31

Rapamycin   improves Graves’ orbitopathy by suppressing CD4+ cytotoxic T   lymphocytes. JCI Insight. 2022 Dec 29;e160377

Meng Zhang, Kelvin Kl   Chong, Zi-Yi Chen, Hui Guo, Yu-Feng Liu, Yong-Yong Kang, Yang-Jun Li,   Ting-Ting Shi, Kenneth Ka Hei Lai, Ming-Qian He, Kai Ye, George J Kahaly,   Bing-Yin Shi, Yue Wang

2023

8

23

Predicting   the early risk of ophthalmopathy in Graves’ disease patients using TCR   repertoire.   Clinical and Translational Medicine. 2020 Nov;10(7):e218

Yue Wang, Yufeng Liu, Xiaofei   Yang, Hui Guo, Jiadong Lin, Jinkui Yang, Mingqian He, Jingya Wang, Xiaomei   Liu, Tingting Shi, Liping Wu, Chengsheng Zhang, Kai Ye*, Bingyin Shi*.

2020

10.6

3

VEGF-A   enhances the cytotoxic function of CD4+ cytotoxic T cells via the   VEGF-receptor 1/VEGF-receptor 2/AKT/mTOR pathway. Journal of Translational   Medicine. 2023

Ziyi Chen; Meng Zhang;   Yufeng Liu; Zhe Chen; Ling Wang; Wenjuan Wang; Jincheng Wang; Mingqian He;   Bingyin Shi; Yue Wang*.

2023

7.5

10

A   preclinical state of Graves' ophthalmopathy characterized by hypoxia of   T-cells identified via multi-omics analysis. Journal of Clinical Endocrinology &   Metabolism. 2025 2025 Apr 11


Zhang, Meng; Qi, Xin; Zhou,   Xingchen; Liu, Yufeng; He,   Mingqian; Wang,   Jingya; Wang, Ling; Chen, Ziyi; Li, Simo; Chen, Yu; Sun, Yushi; Guo, Hui; Yang, Jin; Shi,   Bingyin; Wang, Yue*

2025

5.8


Negative   association between serum calcium and

glucocorticoid-induced   hypertension in thyroid-associated ophthalmopathy patients treated with methylprednisolone.   Frontiers in Endocrinology.


2025

5.2


Hyperlipidemia   and apolipoprotein E are associated with intraocular pressure of   thyroid-associated ophthalmopathy in a Chinese population: a cross-sectional   study. Frontiers   in Endocrinology. 2024 Nov 28:15:1484343

Yu Chen, Xin Qi, Jingya   Wang, Huayang Xu, Yushi Sun, Ling Wang, Xingchen Zhou, Mingqian He, Jiarui   Zhao, Jinbo Zhang, Hairong He, Hui Guo, Bingyin Shi, Yue Wang*, Meng Zhang

2024

5.2


A Promising Mouse Model of Graves’ Orbitopathy   Induced by Adenovirus Expressing Thyrotropin Receptor A Subunit. Thyroid.   2021 Apr;31(4):638-648

Meng Zhang, Xi Ding, Li-ping Wu, Ming-qian He, Zi-yi Chen, Bing-yin   Shi*, Yue Wang*.

2021

6.6

24

Role of Selenium Intake for Risk and Development   of Hyperthyroidism. Journal of Clinical Endocrinology & Metabolism. 2019   Feb 1;104(2):568-580

Yue Wang, Fengyi Zhao, Rijntjes Eddy, Liping Wu, Qian Wu, Jing Sui, Yufeng Liu,   Meng Zhang, Mingqian He, Pu Chen, Shiqian Hu, Peng Hou, Lutz   Schomburg, Bingyin Shi*.

2019

5.8

27

Decreased Treg cell and TCR expansion are   involved in long-lasting Graves' disease. Frontiers in Endocrinology. 2021 Apr   12;12:632492

Ziyi Chen, Yufeng Liu, Shiqian Hu, Meng Zhang, Bingyin Shi*, Yue Wang*.

2021

5.2

14

Leptin receptor is a key gene involved in the   immunopathogenesis of thyroid-associated ophthalmopathy. Journal of Cellular   and Molecular Medicine. 2021 Jun;25(12):5799-5810

Ziyi Chen, Zhe Chen, Jingya Wang, Meng Zhang, Xiaofei Wang, Deji Cuomu,   Bingyin Shi*, Yue Wang*.

2021

5.3

4

Time-restricted eating with or without   low-carbohydrate diet reduces visceral fat and improves metabolic syndrome: A   randomized trial. Cell Rep Med. 2022 Oct 18;3(10):100777.

Mingqian He, Jingya Wang, Qian Liang, Meng Li, Hui Guo, Yue Wang, Cuomu Deji, Jing Sui,   Ya-Wen Wang, Yufeng Liu, Yixuan Zheng, Buyue Qian, Huaixi Chen, Mao Ma, Shi   Su, Hui Geng, Wen-Xu Zhou, Xiaoxiao Guo, Wen-Zhi Zhu, Meng Zhang, Ziyi Chen,   Patrick C N Rensen, Chi-Chung Hui , Yanan Wang, Bingyin Shi

2022

14.3

19

Increased Incidence of Hashimoto Thyroiditis in   Selenium Deficiency: A   Prospective 6-Year Cohort Study. Journal of Clinical Endocrinology &   Metabolism. 2022 Aug 18;107(9):e3603-e3611

Qian Wu, Yue Wang, Ping Chen,   Jing Wei, Hongjun Lv, Si Wang, Yajun Wu, Xuan Zhao, Xiaogang Peng, Eddy   Rijntjes, Youfa Wang, Lutz Schomburg, Bingyin Shi*

2022

5.8

23

Sirolimus versus mycophenolate mofetil for   triple

immunosuppression   in thyroid eye disease patients

with   recent-onset intractable diplopia: A prospective

comparative case series. Clin Exp Ophthalmol

. 2023 Nov;51(8):878-881.

Kenneth K H Lai, Yue Wang, Chi Pui Pang , Kelvin K L Chong

2023

4.9

5

Time-restricted eating with or without

a low-carbohydrate diet improved myocardial

status and thyroid function in individuals

with metabolic syndrome: secondary analysis

of a randomized clinical trial. BMC Med

. 2024 Sep 4;22(1):362.

Yixuan Zheng, Jingya Wang,, Mengmeng Liu, Xingchen Zhou, Xiaoying Lin,   Qian Liang, Jing Yang, Meng Zhang, Ziyi Chen, Meng Li, Yue Wang, Jing   Sui, Wei Qiang Hui Guo, Bingyin Shi ,   Mingqian He

2024

7


Effects of time-restricted eating and low-carbohydrate diet on   psychosocial health and appetite in individuals with metabolic syndrome: A   secondary analysis of a randomized controlled trial. Clin Nutr. 2024 Aug   30;43(10):2316-2324.

Yixuan Zheng, Xin Wang, Jingya Wang , Jing Yang, Ting Wang, Qian Li ,   Wenzhi Zhu , Yue Wang, Jing Sui, Wei Qiang, Hui Guo, Yanan Wang,   Bingyin Shi , Mingqian He

2024

6.6


The proportion of peripheral blood Tregs among   the CD4+ T cells of autoimmune thyroid disease patients: a meta-analysis.   Endocrine Journal. 2020 Mar 28;67(3):317-326

Ziyi Chen, Yue Wang, Xi Ding,   Meng Zhang, Mingqian He, Yang Zhao, Shiqian Hu, Fengyi Zhao, Jingya Wang,   Baosong Xie, Bingyin Shi*.

2020

2

17

Graves' Orbitopathy Models: Valuable Tools for   Exploring Pathogenesis and Treatment.Horm Metab Res.2023 Nov;55(11):745-751

Ling Wang, Meng Zhang, Yue Wang, Bingyin Shi

2023

2.2

0

Dihydrotestosterone regulates oxidative stress   and immunosuppressive cytokines in a female BALB/c mouse model of Graves'   disease. Autoimmunity. 2019 May;52(3):117-125

Fengyi Zhao, Liping Wu, Yue Wang,   Lianye Liu, Fei Yang, Yunshi Sun, Xiang Jiao, Lingyu Bao, Pu Chen, Qian   Liang, Bingyin Shi*

2019

3.5

7

Factors associated with the efficacy of   intravenous methylprednisolone in moderatetosevere and active thyroidassociated ophthalmopathy: A singlecentre retrospective study. Clinical Endocrinology. 2019   Jan;90(1):175-183

Shiqian Hu, Yue Wang,   Mingqian He, Meng Zhang, Xi Ding, Bingyin Shi*.

2018

3.2

7

The Potential Markers Involved in Newly   Diagnosed Graves' Disease and the Development of Active Graves' Orbitopathy.   Cytokine. 2020   Mar;127:154998

Mingqian He , Yue Wang,   Jingya Wang, Jing Sui, Xi Ding, Ziyi Chen, Meng Zhang, Yang Zhao, Baosong   Xie, Bingyin Shi*.

2020

3.8

6

联系方式

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联系电话:13630289316

联系地址: 陕西省西安市朱雀大街277号交大一附院内分泌科



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