张蓬勃

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个人简介

张蓬勃,男,医学博士,教授、主任医师、博士生导师、教育部新世纪优秀人才。1992 年7月毕业于原西安医科大学医学系,毕业后留校从事麻醉学临床、教学、科研工作至今。1998 年获硕士学位,2005 年获博士学位。兼任中国神经科学学会会员,中国心胸血管麻醉学会围术期康复分会副主任委员、中华麻醉学会麻醉生理与生命科学学组副组长、中国心胸血管麻醉学会心血管麻醉分会委员,陕西省麻醉学会、陕西省疼痛学会常委,西安医学会医疗技术鉴定专家,中华医学杂志英文版通讯编委、中华麻醉学杂志编委、西安交通大学学报(医学版)编委等。以第一完成人荣获 “第五届陕西青年科技奖”、陕西省科学技术奖,所带领的团队分别获得西安交通大学创新团队和陕西省重点科技创新团队。


承担主要科研课题

(1)国家自然科学基金项目,82071482,55万元,主持。

(2)陕西省重点科技创新团队建设计划,2014KCT-22 100万元,在研,主持。

(3)陕西省科技统筹创新工程计划项目,2013KTCL03-09 30万元,主持。

(4)国家自然科学基金面上项目,81171247 52万元,结题、主持。

(5)国家自然科学基金面上项目,81071071 30万元,结题,主持。

(6)高等学校博士学科点专项科研基金,20100201110051 6万元、在研、主持。      

(7)教育部新世纪优秀人才支持计划,NCET-08-0436 50万元、已结题、主持。

(8)陕西省科技发展计划项目,2009K16-02、已结题、参加。

(9)国家自然科学基金面上项目,30772081 29万元、已结题、主持。

(10)陕西省“13115”科技创新工程重大科技计划项目,60万元、已结题、参加。

(11)陕西省科技发展计划项目,2007K15-01(17) 2万元、已结题、主持。

(12)国家自然科学基金面上项目,30612755 28万元、已结题、参加。

(13)陕西省科技发展计划项目,2006K13-G5 3万元、已结题、参加。

(14)国家自然科学基金面上项目,30571790 27万元、已结题、参加。

(15)国家自然科学基金面上项目,30570976 25万元、已结题、参加。

(16)陕西省自然科学基金项目,2005C241 1.5万元、已结题、参加。

(17)陕西省科技发展计划项目,2005K15-G1(4) 1.5万元、已结题、参加。

(18)陕西省科技发展计划项目,2005K15-G4(1) 2万元、已结题、参加。

(19)国家自然科学基金面上项目,30300109 20万元、已结题、参加。

(20)国家自然科学基金青年基金项目,30200291 22万元、已结题、主持。

(21)陕西省自然科学基金项目,2002C250 1.5万元、已结题、主持。

(22)陕西省科技发展计划项目,2002K17-G27 1.5万元、已结题、参加。

(23)陕西省科技发展计划项目,2002K10-G1 1.5万元、已结题、参加。


发表主要学术论文


(1) Lei S,Zhang P(通讯作者), Li W, Gao M, He X, Zheng J, Li X, Wang X, Wang N, Zhang J, Qi C, Lu H, Chen X, Liu Y. Pre- and posttreatment with edaravone protects CA1 hippocampus and enhances neurogenesis in the subgranular zone of dentate gyrus after transient global cerebral ischemia in rats. ASN Neuro. 2014 Nov 11;6(6). pii: 1759091414558417. doi: 0.1177/1759091414558417.

(2) Zheng J,Zhang P(通讯作者), Li X, Lei S, Li W, He X, Zhang J, Wang N, Qi C, Chen X, Lu H, Liu Y. Post-Stroke Estradiol Treatment Enhances Neurogenesis in the Subventricular Zone of Rats after Permanent Focal Cerebral Ischemia. Neuroscience. 2013, 12;231:82-90

(3) Zhang J, Shi Q, Yang P, Xu X, Chen X, Qi C, Zhang J, Lu H, Zhao B, Zheng P,Zhang P(通讯作者), Liu Y. Neuroprotection of neurotrophin-3 against focal cerebral ischemia/reperfusion injury is regulated by hypoxia-responsive element in rats.Neuroscience. 2012,11;222:1-9.

(4) Zhang P, Li W, Li L, Wang N, Li X, Gao M, Zheng J, Lei S, Chen X, Lu H, Liu Y. Treatment with edaravone attenuates ischemic brain injury and inhibits neurogenesis in the subventricular zone of adult rats after focal cerebral ischemia and reperfusion injury. Neuroscience. 2012, 201:297-306.

(5)Zhang P, Liu Y, Li J, Kang Q, Tian Y, Chen X, Zhao J, Shi Q, Song T. Decreased neuronal nitric oxide synthase expression and cell migration in the peri-infarction after focal cerebral ischemia in rats. Neuropathology. 2007, 27(4):347-354.

(6)Zhang P, Li J, Liu Y, Chen X, Lu H, Kang Q, Li W, Gao M. Human embryonic neural stem cell transplantation increases subventricular zone cell proliferation and promotes peri-infarct angiogenesis after focal cerebral ischemia. Neuropathology. 2011, 31(4):384-391.

(7)Shi Q,Zhang P, Zhang J, Chen X, Lu H, Tian Y, Parker T, Liu Y. Adenovirus-mediated brain-derived neurotrophic factor expression regulated by hypoxia response element protects brain from injury of transient middle cerebral artery occlusion in mice. Neurosci Lett. 2009, 465(3):220-225.

(8)Zhang P, Li J, Liu Y, Chen X, Kang Q. Transplanted human embryonic neural stem cells survive, migrate, differentiate and increase endogenous nestin expression in adult rat cortical peri-infarction zone. Neuropathology. 2009, 29(4):410-421.

(9)Zhang P, Li J, Liu Y, Chen X, Kang Q, Zhao J, Li W. Human neural stem cell transplantation attenuates apoptosis and improves neurological functions after cerebral ischemia in rats. Acta Anaesthesiol Scand. 2009, 53(9):1184-1191.

(10)Lu H, Li M, Song T, Qian Y, Xiao X, Chen X,Zhang P, Feng X, Parker T, Liu Y. Retrovirus delivered neurotrophin-3 promotes survival, proliferation and neuronal differentiation of human fetal neural stem cells in vitro. Brain Res Bull. 2008, 77(4):158-164.

(11)Zhang P, Liu Y, Li J, Kang Q, Tian Y, Chen X, Shi Q, Song T. Cell proliferation in ependymal/subventricular zone and nNOS expression following focal cerebral ischemia in adult rats. Neurol Res. 2006, 28(1):91-96.

(12)Lu Y, Lei S, Wang N, Lu P, Li W, Zheng J, Giri PK, Lu H, Chen X, Zuo Z, Liu Y and Zhang P(通讯作者). Protective Effect of Minocycline Against Ketamine-Induced Injury in Neural Stem Cell: Involvement of PI3K/Akt and Gsk-3 Beta Pathway. Front. Mol. Neurosci. 2016; 9:135. doi: 10.3389/fnmol.2016.00135

(13)Wei, Z., Jingyi Zhao, Yongmei Chen,Pengbo Zhang(通讯作者), Qiqing Zhang. Self-healing polysaccharide-based hydrogels as injectable carriers for neural stem cells. Sci. Rep. 2016;6, 37841; doi: 10.1038/srep37841.

(14) Li Q, Qiu Z, Lu Y, Lu P, Wen J, Wang K, Zhao X, Li R, Zhang H, Zhang Y, Jia P, Fan P, Zhang Y, Zhang S, Lu H, Chen X, Liu Y,Zhang Pg(通讯作者). Edaravone protects primary-cultured rat cortical neurons from ketamine-induced apoptosis via reducing oxidative stress and activating PI3K/Akt signal pathway.Mol Cell Neurosci. 2019 Sep 7;100:103399. doi: 10.1016/j.mcn.2019.103399.

(15) Li W, Li H, Wei H, Lu Y, Lei S, Zheng J, Lu H, Chen X, Liu Y,Zhang Pg(通讯作者). 17β-Estradiol Treatment Attenuates Neurogenesis Damage and Improves Behavior Performance After Ketamine Exposure in Neonatal Rats. Front Cell Neurosci. 2019 Jun 13;13:251. doi: 10.3389/fncel.2019.00251.

(16) Lu P, Lei S, Li W, Lu Y, Zheng J, Wang N, Xia Y, Lu H, Chen X, Liu Y, Zhang PB(通讯作者). Dexmedetomidine Protects Neural Stem Cells from Ketamine-Induced Injury. Cell Physiol Biochem. 2018;47(4):1377-1388. doi: 10.1159/000490823.

(17) Wang N, Lu Y, Wang K, Li WS, Lu P, Lei S, Li R, Zhang H, Zheng J, Lu HX, Chen XL, Liu Y, Zhang PB(通讯作者). Simvastatin Attenuates Neurogenetic Damage and Improves Neurocongnitive Deficits Induced by Isoflurane in Neonatal Rats. Cell Physiol Biochem. 2018;46(2):618-632. doi: 10.1159/000488630.

(18) Giri PK, Lu Y, Lei S, Li W, Zheng J, Lu H, Chen X, Liu Y,Zhang P(通讯作者). Pretreatment with minocycline improves neurogenesis and behavior performance after midazolam exposure in neonatal rats. Neuroreport. 2018 Feb 7;29(3):153-159. doi: 10.1097/WNR.0000000000000937.

(19) Lu Y, Giri PK, Lei S, Zheng J, Li W, Wang N, Chen X, Lu H, Zuo Z, Liu Y,Zhang P(通讯作者). Pretreatment with minocycline restores neurogenesis in the subventricular zone and subgranular zone of the hippocampus after ketamine exposure in neonatal rats. Neuroscience. 2017 Jun 3;352:144-154. doi: 10.1016/j.neuroscience.2017.03.057.

(20) Lu Y, Lei S, Wang N, Lu P, Li W, Zheng J, Giri PK, Lu H, Chen X, Zuo Z, Liu Y,Zhang P(通讯作者). Protective Effect of Minocycline Against Ketamine-Induced Injury in Neural Stem Cell: Involvement of PI3K/Akt and Gsk-3 Beta Pathway. Front Mol Neurosci. 2016 Dec 20;9:135. doi: 10.3389/fnmol.2016.00135.


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