高蕊，主任医师，硕士研究生导师，博士研究生合作导师；
研究方向：分子影像在肿瘤及神经退行性疾病应用
联系方式：jacky_mg@163.com
个人及工作简历：西安交通大学第一附属医院核医学科党支部书记，影像医学与核医学博士，Johns Hopkins Medical Institutions 访问学者。中华医学会核医学分会学组委员，中国核学会核医学分会青年委员，中国医师协会核医学医师分会青年委员，中国医疗保健国际交流促进会甲状腺疾病分会青年委员。国家自然科学基金一审专家，Contrast Media & Molecular Imaging, Frontiers in neurology等SCI杂志审稿人。2014至2019年连续获邀参加美国分子影像与核医学协会年会进行大会交流。
科研项目：
1. 国家自然科学基金青年基金项目、81273148、基于差异蛋白组学与功能影像学的头针治疗帕金森病机理研究、2011/1-2013/12、20万元、已结题、主持。
2. 国家自然科学基金青年基金项目、81302917、基于非线性动力学与噪声随机共振理论的经络腧穴钙离子振荡研究、2014/1-2016/12、23万元、已结题、参与。
3. 国家自然科学基金面上项目、81172598、甲亢细胞对放射性131碘辐射敏感个体性差异的基因机制研究、2012/1-2015/12、55万元、已结题、参与。
4. 陕西省自然科学项目、2016JM8056、针刺对左旋多巴诱发异动症中多巴胺能D2受体影响的研究、2016/1-2017/1、5万元、已结题、主持。
5. 中华国际医学交流基金会2017甲状腺中青年医生研究项目、RGD分子影像在分化型甲状腺癌患者危险度评估中的应用研究、2017.10-2018.10、5万元、已结题、主持。
6. 西安交大一附院临床研究课题面上项目、XJTU1AF-CRF-2017-011、99mTc-3PRGD2 SPECT/CT和18F-FDG PET/CT在分化型甲状腺癌患者危险度评估中的应用研究、2018.04-2021.03、5万元、在研、主持。
7. 国家自然科学基金面上项目、81871389、甲状腺细胞放射敏感性差异对分化型甲状腺癌131碘治疗决策影响的研究、2019.1-2020.12、25万元、在研、第二完成人。
代表性论文：
1. Gao Rui, Zhang Guangjian, Fu Junke, Jin Xin, Zhang Mingxin, Li Fen. The influence of fractioned irradiation on HIF-1α and MDR1 expression in esophageal cancer cell [J]. J South Med Univ 2010, 30(5):1037-1040.
2. Zhang Guangjian, Gao Rui, Fu Junke, Jin Xin, Zhang Mingxin, Wang Jiansheng. Expressions of MDR1 and HIF-1α in esophageal carcinoma and their clinical significance[J]. Journal of Xi’an Jiaotong University (Medical Sciences) 2010, 31(6):724-727.
3. Zhang Guangjian, Gao Rui, Jin Xin, Yu Zhonglin. Treatment of 84 cases of blood oozing in postoperative wounds in esophageal carcinoma by Yunnan Baiyao [J]. Shanghai Journal of Traditional Chinese Medicine 2011, 1(1):145-146.
4. Zhang Guangjian, Gao Rui, Qiu Genquan, Fu Junke, Jin Xin. Treatment of hemothorax supplemented by Xuefu Zhuyu Decoction: Its curative effect and influence on coagulation state [J]. Journal of Xi’an Jiaotong University (Medical Sciences), 2011, 5: 632-635.
5. Zhang Guangjian, Gao Rui, Wang Jiansheng, Fu Junke, Zhang Mingxin, Jin Xin. Various doses of fractioned irradiation modulates multidrug resistance 1 expression differently through hypoxia-inducible factor 1a in esophageal cancer cells [J]. Dis Esophagus, 2011, 24(7):481-488.
6. Zhang GuangJian, Gao Rui, Fu JunKe, Jin Xin, Zhang Yong, Wang Zhe. Climatic Conditions and the Onset of Spontaneous Pneumothorax –A Solar Term Influence Investigation [J]. Med Princ Pract, 2012; 21:345–349.
7. Gao Rui, Zhang Guangjian, Wang Yong, Feng Jie, Cui Yanchao, Jia Xi, Li Fen. High frequency electro-acupuncture enhances striatum DAT and D1 receptor expression, but decreases D2 receptor level in 6-OHDA lesioned rats [J]. Behavioural Brain Research, 2013; 237:263–269.
8. Gao Rui, Jiang Yina, Fu Junke, Zhang Guangjian. Etiological study of benign esophageal dysphagia with only granulation- Report of two cases [J]. Journal of Medical Colleges of PLA, 2013, 28: 174-182.
9. Gao R, Zhang Y, Wen XP, Fu JK, Zhang GJ. Chemotherapy with cisplatin or carboplatin in combination with etoposide for small-cell esophageal cancer: a systemic analysis of case series. Diseases of the Esophagus 2014;27: 764-769
10. Gao R, Zhang G, Chen L, Zhu Z, Wang F, Yang A. Utility of Tc-PEG4-E[PEG4-c(RGDfK)]2 in Posttherapy Surveillance of Patients with Reelevated Carcinoembryonic Antigen Levels. Med Princ Pract.2015;24(3):244-9.
11. Zhang W, Gao R, Yu Y, Guo K, Hou P, Yu M, Liu Y, Yang A. Iodine-131 induces apoptosis in HTori-3 human thyrocyte cell line and G2/M phase arrest in a p53-independent pathway. Mol Med Rep. 2015;11(4):3148-54.
12. Guo K, Gao R, Yu Y, Zhang W, Yang Y, Yang A. Quantitative mRNA expression analysis of selected genes in patients with early-stage hypothyroidism induced by treatment with iodine-131. Mol Med Rep. 2015;12(5):7673-80.
13. Gao R, Zhang G, Chen X, Yang A, Smith G, Wong DF, Zhou Y. CSF Biomarkers and Its Associations with 18F-AV133 Cerebral VMAT2 Binding in Parkinson's Disease-A Preliminary Report. PLoS One 2016;11(10):e0164762.
14. Gao R, Zhang G, Chen X, Reid S, Zhou Y. 18F-AV133 Cerebral VMAT2 Binding Correlated with α-synuclein Spliced Variants in Parkinson’s Disease. J Neuroimaging Psychiatry Neurol. 2016; 1(1): 4-9.
15. Gao R, Zhang G, Chen X, Reid S, Zhou Y. Associations between 18F-AV133 Cerebral VMAT2 Binding and Plasma LDL and HDL Levels in Parkinson’s Disease. J Neuroimaging Psychiatry Neurol. 2016; 1(1): 20-26.
16. Gao R, Gao S, Feng J, Wang Y, Zhang G. Diffuse Thyroid Metastasis from Lung Cancer Mimicking Thyroiditis on 99mTc-Pertechnetate Scintigraphy. Clin Nucl Med.2017;42(9):690-691.
17. Gao R, Gao S, Feng J, Cui H, Cui Y, Fu J, Zhang G. Effect of Electroacupuncture on 99mTc-Sodium Pertechnetate Uptake and Extracellular Fluid Free Molecules in the Stomach in Acupoint ST36 and ST39. Sci Rep.2018;8(1):6739.
18. Rui Gao, Xi Jia, Ting Ji, Jinteng Feng, Aimin Yang, Guangjian Zhang. Management and Prognostic Factors for Thyroid Carcinoma Showing Thymus-Like Elements (CASTLE): A Case Series Study. Front Oncol.2018; 8:477.
19. Gao R, Zhang GJ, Wang YB, Liu Y, Wang F, Jia X, Liang YQ, Yang AM. Clinical Value of 99mTc-3PRGD2 SPECT/CT in Differentiated Thyroid Carcinoma with Negative 131I Whole-Body Scan and Elevated Thyroglobulin Level. Sci Rep. 2018;8(1):473.
20. Gao R, Jia X, Liang Y, Fan K, Wang X, Wang Y, Yang L, Yang A, Zhang G. Papillary Thyroid Micro Carcinoma: The Incidence of High-Risk Features and Its Prognostic Implications. Front Endocrinol (Lausanne). 2019 Feb 15;10:74.
21. Rui Gao, Shan Gao, Xi Jia, Hongyan Wang, Guangjian Zhang. Ectopic papillary thyroid carcinoma mimicking esophageal cancer in FDG PET: A case report. Clin Nucl Med. 2019 Jan;44(1):59-60.
